| Cat. No. |
Product Name |
Information |
| PC-26432 |
BDM35899
IDE activator
|
BDM35899 is a small activator of insulin degrading enzyme (IDE) with pEC50 of 5.3, binds to polyanion-binding site of IDE, activates both Aβ and insulin hydrolysis by IDE, decreases glucose-stimulating insulin secretion in β-pancreatic cells. |
| PC-26431 |
BDM43124
IDE inhibitor
|
BDM43124 is the methyl ester precursor of BDM43079, which is a selective inhibitor of insulin degrading enzyme (IDE) with IC50 of 0.1 uM, inhibits the hydrolysis of amyloid-β1-40 by IDE in in SH-SY5Y cells. |
| PC-26430 |
BDM43079
IDE inhibitor
|
BDM43079 is a selective small molecule inhibitor of insulin degrading enzyme (IDE) with IC50 of 0.1 uM, selective of hIDE versus a panel of metalloproteases including hNEP. |
| PC-26428 |
BDM71230
IDE activator
|
BDM71230 is a potent, small molecule Insulin-Degrading Enzyme (IDE) activator with EC50 of 1.9 uM in glucose stimulated insulin secretion (GSIS) by pancreatic β-cells assay, 4.1-fold activation at 100 uM. |
| PC-26427 |
PKR1 agonist IS39
PKR1 agonist
|
PKR1 agonist IS39 is a selective, metabolically stable, non-peptide Prokineticin receptor-1 (PKR1, PROKR1) agonist, protects cardiomyocytes from doxorubicin-induced cytotoxicity. |
| PC-26426 |
APE1 inhibitor C10
APE1 inhibitor
|
APE1 inhibitor C10 (Refi-10) is a specific small molecule inhibitor of redox activity of APE1 with binding affinity (SPR Kd) of 189 nM, inhibits the redox function, but not the DNA repair function of APE1. |
| PC-26420 |
MKI-3
MASTL inhibitor
|
MKI-3 (MASTL kinase inhibitor-3) is a potent and selective MASTL (Greatwall kinase) inhibitor with IC50 of 5.72 nM, binds to MASTL with BLI KD of 1.89 nM. |
| PC-26403 |
GPR61 inverse agonist 15
GPR61 inverse agonist
|
GPR61 inverse agonist 15 is a potent, selective, and brain-penetrant GPR61 inverse agonist with cAMP functional IC50 of 6.2 nM and 20 nM for human and mouse GPR61 respectively. |
| PC-26402 |
GPR61 inverse agonist 23
GPR61 inverse agonist
|
GPR61 inverse agonist 23 is a potent, selective, and brain-penetrant GPR61 inverse agonist with cAMP functional IC50 of 4.0 nM and 8.8 nM for human and mouse GPR61 respectively. |
| PC-26391 |
ONO-7068506
GCLC inhibitor
|
ONO-7068506 (GCLCi1) is a potent, selective glutamylcysteine ligase catalytic subunit (GCLC) inhibitor, shows potent anti-tumor effects in SMARCB1-deficient cancer cells. |
| PC-26390 |
ONO-6428513
GCLC inhibitor
|
ONO-6428513 (GCLCi0) is a potent, selective glutamylcysteine ligase catalytic subunit (GCLC) inhibitor, shows potent anti-tumor effects in SMARCB1-deficient cancer cells. |
| PC-26389 |
CZ-48
SARM1 activator
|
CZ-48 (Sulfo-ara-F-NMN) is a mimetic of nicotinamide mononucleotide (NMN) and selective cell-permeant activator of SARM1, activate SARM1 to produce cADPR from NAD, does not inhibit CD38. |
