| Cat. No. |
Product Name |
Information |
| PC-25994 |
LP-856866
ACSL5 inhibitor
|
LP-856866 (ACSL5i) is a potent, selective inhibitor of Acyl-CoA Synthetase 5 (ACSL5) with IC50 of 4 nM and 8 nM for huamn and mouse ACSL5 in acyl-CoA synthetase (ACS) assays, highly selective against ACSL3. |
| PC-25980 |
AVIL inhibitor Compound A
Advillin inhibitor
|
AVIL inhibitor Compound A (PLH1215) is a specific small molecule actin-binding protein advillin (AVIL)-interacting compound with MST Kd of 6 uM, also blocks AVIL binding to its substrate actin. |
| PC-25859 |
Lysosome inhibitor LLAD
SLC38A9 inhibitor
|
LLAD is a long-term lysosome-targeting anticancer drug, inhibits SLC38A9 in lysosomes and alkalinizes lysosomes, induces apoptosis through long-term lysosomal damage in vivo and in vitro. |
| PC-25857 |
PF-429242 dihydrochloride
S1P inhibitor
|
PF-429242 dihydrochloride (PF429242) is a potent, selective, reversible and competitive inhibitor of proprotein convertase SREBP site 1 protease (S1P, Subtilisin kexin isozyme-1/SKI-1, MBTPS1) with IC50 of 170 nM. |
| PC-25818 |
DS89092425
PUF60-UHM inhibitor
|
DS89092425 is a small molecule RNA splicing factor PUF60-UHM inhibitor with ITC KD of 83 uM. |
| PC-25817 |
Claudin 5 binder CL5B
CLDN5 binder
|
Claudin 5 binder CL5B is a small molecule binder of Claudin 5 (CLDN5), binds directly to hCLDN5 with KD of 31.7 uM, opens the blood-brain barrier and safely enhances brain drug delivery. |
| PC-25807 |
Ciliogenesis inhibitor Nao-3
Ciliogenesis inhibitor
|
Ciliogenesis inhibitor Nao-3 (Naonedin-3) is specific small-molecule inhibitor of ciliogenesis, represses primary ciliogenesis and induces the death of chemoresistant ciliated stem-like cells. |
| PC-25797 |
JPC0661
ΔFOSB inhibitor
|
JPC0661 is a specific small molecule direct inhibitor of AP1 transcription factor ΔdeltaFOSB (ΔFOSB), inhibits FOSB/JUND and ΔFOSB DNA-binding biochemically with IC50 of 9 uM and 52 uM respectively. |
| PC-25712 |
RWT9996
GPR17 antagonist
|
RWT9996 is a potent, selective GPR17 antagonist, inhibits both G protein activation and β-arrestin-2 recruitment. |
| PC-25682 |
Ferovicin
FERONIA receptor inhibitor
|
Ferovicin is a specific small molecule inhibitor FERONIA (FER) receptor kinase with IC50 of 70 nM, selectively binds to the ATP-binding pocket of the kinase domain of FER and inhibits its kinase activity. |
| PC-25675 |
JNJ-9350
Spermine oxidase inhibitor
|
JNJ-9350 is a potent, selective Spermine oxidase (SMOX) inhibitor with IC50 of 8 nM for human SMOX (hSMOX), shows remarkable selectivity over hPAOX (>89-fold). |
| PC-25661 |
TDRL-505
RPA inhibitor
|
TDRL-505 is a small molecule inhibitor of Replication protein A (RPA) with IC50 of 13 uM, inhibits RPA's DNA binding activity targeting DBD-A and B in the 70 kDa subunit of RPA. |
