| Cat. No. |
Product Name |
Information |
| PC-24661 |
Core Circadian Modulator
BMAL1 ligand
|
Core Circadian Modulator (CCM) is specific small molecule BMAL1 ligand, targets the cavity in the PASB domain of BMAL1 with ITC Kd of 1.99 uM, modulates BMAL1-CLOCK target gene expressions. |
| PC-24650 |
Cucurbitacin B
IGF2BP1 inhibitor
|
Cucurbitacin B (CuB) is a potent but toxic anticancer natural product, an irreversible covalent inhibitor of IGF2BP1 and forms a covalent bond with cysteine 253 of the IGF2BP1 KH 1-2 domain (KD=66.8 nM). |
| PC-24626 |
RJG-2036
PTGR2 inhibitor
|
RJG-2036 is a potent, selective, covalent prostaglandin reductase 2 (PTGR2) inhibitor with IC50 of 100 nM (human PTGR2), covalently ligands the noncatalytic Y100 and Y265 residues located in the substrate binding pocket. |
| PC-24621 |
Fis1 inhibitor SP11
Fis1 inhibitor
|
SP11 is a potent inhibitor of activated Fis1 (mitochondrial fission protein 1), covalently binds specifically to Cys41 of activated Fis1, inhibits CPM fluorescence of Thr34Asp Fis1 with IC50 of 9.4 uM. |
| PC-24616 |
ORIC-533
CD73 inhibitor
|
ORIC-533 is a potent, selective, AMP-competitive and orally bioavailable ectonucleotidase CD73 inhibitor. |
| PC-24596 |
SALL4 inhibitor SH6
SALL4 degrader
|
SALL4 inhibitor SH6 is a small molecule inhibitor of transcription factor SALL4 ZFC4 domain, selectively targets SALL4-expressing cancer cells (EC50=0.5 uM, SNU398 cells), degrades SALL4 protein through the CUL4A/CRBN pathway. |
| PC-24547 |
Fascin inhibitor G2
Fascin inhibitor
|
Fascin inhibitor G2 is a small molecule inhibitor of Fascin (FSCN1), inhibits the actin-bundling function of fascin with IC50 of 5-8 uM, blocks tumour invasion and metastatic colonization. |
| PC-24546 |
NP-G2-029
Fascin inhibitor
|
NP-G2-029 is a specific small molecule inhibitor of Fascin (FSCN1) with IC50 of 0.19 uM in F-actin-bundling assay, decreases the migration of mouse and human breast tumor cells. |
| PC-24478 |
CLEC-2 inhibitor MAS9
CLEC-2 inhibitor
|
MAS9 is a specific small molecule inhibitor targeting the C-type lectin-like receptor-2 (CLEC-2)-podoplanin interaction with IC50 of 4.5 uM, inhibits CLEC-2-mediated platelet aggregation. |
| PC-24451 |
Mitochondrial complex I inhibitor C458
Mitochondrial complex I modulator
|
C458 is a nontoxic mitochondrial complex I (mtCI) inhibitor with highly protective against Aβ toxicity, C458 protects MC65 Tet-Off cells (Aβ expressed) with an EC50 of 4.6 nM. |
| PC-24394 |
BCT1028
BLVRB inhibitor
|
BCT1028 is a potent, selective small molecule Biliverdin IXβ reductase (BLVRB) inhibitor with IC50 of 195 nM (50 uM BLVRB substrate DCPIP). |
| PC-24385 |
HEX-1
Pin1 inhibitor
|
HEX-1 is a valuable addition to the armamentarium against CRC, suppresses the proliferation of cancer cells and tumorigenesis via the inactivation and sensitization of PIN1. |
