| Cat. No. |
Product Name |
Information |
| PC-25315 |
PRDX1 inhibitor 7e
PRDX1 inhibitor
|
PRDX1 inhibitor 7e (PRDX1-IN-1) is a potent peroxiredoxin 1 (PRDX1) inhibitor with IC50 of 164 nM. |
| PC-25314 |
UNI110
CAS 2648334-60-3
|
UNI110 is a potent small molecule inhibitor of mismatch repair (MMR)-deficient cancer cells, selectively kills MutSa deficient cells with IC50 of 25.05 µM in HEC59 cells and 56.57 µM in HEC59-2 cells. |
| PC-25283 |
KG022
hairpin RNAs binder
|
KG022 is a fluoroquinolone derivative, binds specifically to the bulge-out region of hairpin RNAs, binds to RNA-C and RNA-G stronger than RNA-A and RNA-U based on the exchange rates. |
| PC-25280 |
PTC-775
MAPT splicing modulator
|
PTC-775 is a potent splicing modulator compound (SMC) that correct microtubule-associated protein tau (MAPT) splicing with EC2x value of 4.9 nM in MAPT minigene assay in HEK293T cells (3R MAPT), promotes MAPT exon 10 exclusion, increasing 3R MAPT transcript and protein levels. |
| PC-25277 |
PTC-003
MAPT splicing modulator
|
PTC-003 is a potent splicing modulator compound (SMC) that correct microtubule-associated protein tau (MAPT) splicing with EC2x value of 5.2 nM in MAPT minigene assay in HEK293T cells (3R MAPT), promotes MAPT exon 10 exclusion, increasing 3R MAPT transcript and protein levels. |
| PC-25275 |
Cycloleucine
MAT2A inhibitor
|
Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation, is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro, also inhibits MAT2A, Cycloleucine is an antagonist of NMDA receptor associated glycine receptor. |
| PC-25274 |
AGI-24512
MAT2A inhibitor
|
AGI-24512 is a highly potent, cell-active methionine adenosyltransferase 2α (MAT2A) inhibitor with enzymatic IC50 of 8 nM. |
| PC-25260 |
IPR-3242
uPAR-uPA inhibitor
|
IPR-3242 is a small molecule inhibitor of the uPAR·uPA protein-protein interaction, inhibits the uPAR·uPAATF interaction with IC50 of 8.6 uM. |
| PC-25259 |
IPR-803
uPAR-uPA inhibitor
|
IPR-803 is a small molecule inhibitor of the uPAR·uPA protein-protein interaction, binds directly to uPAR with sub-micromolar affinity of 0.2 uM. |
| PC-25258 |
IPR-456
uPAR-uPA inhibitor
|
IPR-456 is a small molecule inhibitor of the uPAR·uPA protein-protein interaction, binds to uPAR with Kd of 310 nM, inhibits uPA binding to uPAR of breast MDA-MB-231 tumor cells with IC50 of 8 uM. |
| PC-25256 |
Profilin-1 inhibitor UP-6
Profilin-1 inhibitor
|
Profilin-1 inhibitor UP-6 is a specific small molecule inhibitor of actin-binding protein profilin-1 (Pfn1), inhibits Pfn1-actin interaction and shows potent anti-angiogenic activity in vitro and in vivo. |
| PC-25255 |
Pfn1-actin interaction inhibitor C74
Profilin-1 inhibitor
|
Pfn1-actin interaction inhibitor C74 is a specific small molecule inhibitor of profilin1 (Pfn1)-actin interaction, reduces RCC cell proliferation in vitro and tumor growth in vivo. |
