| Cat. No. |
Product Name |
Information |
| PC-26403 |
GPR61 inverse agonist 15
GPR61 inverse agonist
|
GPR61 inverse agonist 15 is a potent, selective, and brain-penetrant GPR61 inverse agonist with cAMP functional IC50 of 6.2 nM and 20 nM for human and mouse GPR61 respectively. |
| PC-26402 |
GPR61 inverse agonist 23
GPR61 inverse agonist
|
GPR61 inverse agonist 23 is a potent, selective, and brain-penetrant GPR61 inverse agonist with cAMP functional IC50 of 4.0 nM and 8.8 nM for human and mouse GPR61 respectively. |
| PC-26391 |
ONO-7068506
GCLC inhibitor
|
ONO-7068506 (GCLCi1) is a potent, selective glutamylcysteine ligase catalytic subunit (GCLC) inhibitor, shows potent anti-tumor effects in SMARCB1-deficient cancer cells. |
| PC-26390 |
ONO-6428513
GCLC inhibitor
|
ONO-6428513 (GCLCi0) is a potent, selective glutamylcysteine ligase catalytic subunit (GCLC) inhibitor, shows potent anti-tumor effects in SMARCB1-deficient cancer cells. |
| PC-26378 |
Z-5891
COPS3 inhibitor
|
Z-5891 is a highly selective COPS3 inhibitor, exhibits concentration-dependent proliferation-inhibitory activity against 143B cells with IC50 of 3.28 uM. |
| PC-26374 |
Aflatoxin B1
1162-65-8
|
Aflatoxin B1 (AFB1) is a Group 1A carcinogen and a secondary metabolite produced by Aspergillus flavus and A. parasiticus, can induces mutations by causing a G to T transversion at the third nucleotide of codon 249 in the tumor suppressor gene p53. |
| PC-26340 |
Mezodriton
Mitochondrial uncoupler
|
Mezodriton is a small molecule mitochondrial oxidative phosphorylation uncoupler. |
| PC-26323 |
Dinifedriton
Mitochondrial uncoupler
|
Dinifedriton is a small molecule mitochondrial uncoupler for regulating mitochondria activity and reducing adiposity in the treatment of diseases. |
| PC-26308 |
GIT1/β-Pix inhibitor 14-5-18
GIT1/β-Pix inhibitor
|
GIT1/β-Pix inhibitor 14-5-18 is a small-molecule inhibitor to interrupt the protein–protein interaction (PPI) of GIT1/β-Pix complex with Ki of 1.8 uM in FP assays, directly binds to GIT1 with BLI KD of 7.7 uM, inhibits gastric cancer metastasis. |
| PC-26306 |
GIT1 inhibitor Compound 3
GIT1 inhibitor
|
GIT1 inhibitor Compound 3 (GIT1-IN-C3) is a selective small molecule inhibitor of ARF GTPase protein 1 (GIT1) with MST KD of 6.2 uM, effectively disrupts GIT1 from interacting with MAT2B and RAF/MEK/ERK to halt cancer cell growth in vitro and in vivo. |
| PC-26292 |
STK189682
RNA helicase inhibitor
|
STK189682 is a potent small molecule inhibitor of RNA helicases MDA5, LGP2, and DDX1 with IC50 of 7 uM, 7 uM and 5 uM in ATPase assays. |
| PC-26275 |
Rebaudioside N
SBK2 agonist
|
Rebaudioside N is a terpenoid glycoside isolated from the leaves of Stevia rebaudiana Bertoni, is a potent SH3 domain-binding kinase 2 (SBK2) agonist, effectively suppresses NLRP3-mediated IL-1β/IL-18 secretion, reduces inflammatory responses, and diminishes atherosclerotic burden. |
