| Cat. No. |
Product Name |
Information |
| PC-28155 |
PH521
SARS-CoV-2 PLpro inhibitor
|
PH521 is a potent, specific and competitive SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 0.14 uM, shows >700-fold selectivity over other cysteine proteases including SARS-CoV-2 Plpro, human CatL and T. cruzi Cruzain. |
| PC-28154 |
ID3-77
SARS-CoV-2 PLpro inhibitor
|
ID3-77 is a potent, covalent inhibitor of SARS-CoV-2 papain-like protease (PLpro) with IC50 of 209 nM, produces strong antiviral effect, reducing viral titer by 5.48 and 5.50 log units at 1 and 10 uM, respectively. |
| PC-27776 |
AVI8122
Coronaviruse Mpro inhibitor
|
AVI8122 is a potent, covalent pan-coronaviral inhibitor targets 19 main proteases (Mpro) across the α, β, γ, and δ genera, encompassing bat, human, and other animal coronaviruses. |
| PC-27676 |
SRC-1 inhibitor 10
NCOA1 inhibitor, SARS-CoV-2 inhibitor
|
SRC-1 inhibitor 10 is a small molecule SARS-CoV-2 replication inhibitor targeting host lipogenesis, potently inhibits replication of both the prototypic and BA.1 variants with EC50 of 0.9 and 0.5 uM respectively, binds to and promotes degradation of nuclear receptor coactivator 1 (NCOA1, SRC-1). |
| PC-27482 |
Nosidesivir
Viral RdRp inhibitor
|
Nosidesivir (NGP-1) is a prodrug of GS-441524 with potential anti-SARS-CoV-2 activity, and increased lipophilicity, absorption, and bioavailability. |
| PC-26854 |
AS-0017445
Mpro inhibitor
|
AS-0017445 (ASAP-0017445) is a broad-spectrum coronavirus antiviral inhibitor that targets the main protease (Mpro) of Middle East respiratory syndrome (MERS) and SARS-CoV-2. |
| PC-25823 |
Avoralstat
Plasma kallikrein inhibitor, TMPRSS2 inhibitor
|
Avoralstat (BCX4161) is a potent and orally active plasma kallikrein inhibitor, also is a potent, selective Transmembrane protease, serine 2 (TMPRSS2) inhibitor (IC50=2.73 nM). |
| PC-25814 |
DY-III-281
SARS-CoV entry inhibitor
|
DY-III-281 is a SARS-CoV-2 small-molecule entry inhibitor with IC50 of 0.62 uM and 0.44 uM for SARS-CoV-1-S and SARS-CoV-2-S pseudoviruses. |
| PC-25647 |
SARS-CoV-2 NSP14 inhibitor C10
SARS-CoV-2 NSP14 inhibitor
|
SARS-CoV-2 NSP14 inhibitor C10 is a potent, selective non-nucleoside inhibitor of SARS-CoV-2 nonstructural protein 14 (NSP14) with IC50 of 0.34 uM, exhibits potent antiviral activity and reverses NSP14-driven host modulation. |
| PC-24849 |
KCO237
SARS-CoV-2 Nsp15 inhibitor
|
KCO237 is a potent, reversible, non-covalent inhibitor of SARS-CoV-2 Nsp15 endoribonuclease with IC50 of 304 nM, inhibits VERO 6 cell infection with SARS-CoV-2. |
| PC-24641 |
ISM3312
Mpro inhibitor
|
ISM3312 is a potent, irreversible covalent broad-spectrum inhibitor of human coronavirus main protease (Mpro) with IC50 of 14 nM, exhibits potent cellular potency in VeroE6 cell lines with EC50 of 71 nM. |
| PC-24517 |
N-0920
TMPRSS2 inhibitor
|
N-0920 (Cbz-QFR-kt) is highly potent, specific TMPRSS2 inhibitor with IC50 of 350 pM, displays high antiviral potency with IC50 of 0.3 nM and 0.09 nM for SARS-CoV-2 Variants EG.5.1 and JN.1 respectively. |
