| Cat. No. |
Product Name |
Information |
| PC-22523 |
PF-07799933
mutant BRAF inhibitor
|
PF-07799933 (Claturafenib, ARRY-440) is a brain-penetrant, selective, pan-mutant BRAF inhibitor, demonstrated broad inhibition of pERK levels in cell lines harboring Class I (IC50=0.7-7 nM), II (10-14 nM), III (0.8, 7.8 nM), and indel (113, 179 nM) mutations, acquired BRAF p61 splice variant (59 nM), and acquired NRAS-Q61K (16 nM), but significantly spared pERK in BRAF wild-type cells (≥9800 nM). |
| PC-22122 |
NST-628
RAF-MEK molecular glue
|
NST-628 is a potent, brain-penetrant, pan-RAF-MEK molecular glue, prevents phosphorylation and activation of MEK by RAF, leading to deep durable inhibition of MEK kinase activity and downstream ERK signaling. |
| PC-21386 |
Uplarafenib
BRAF inhibitor
|
Uplarafenib is a potent, selective small molecule inhibitor of BRAF kinase (IC50=50-100 nM) with antineoplastic activities. |
| PC-21219 |
Exarafenib
pan-RAF inhibitor
|
Exarafenib (KIN-2787) is a highly potent and selective pan-RAF inhibitor with IC50 of 2.4/3.5/1.4 nM for ARAF/BRAF/CRAF, respectively. |
| PC-20793 |
IHMT-RAF-128
pan-RAF inhibitor
|
IHMT-RAF-128 is a highly potent pan-RAF inhibitor with IC50 of 5.9 and 3.6 nM for BRAF-V600E and CRAF, respectively. |
| PC-49770 |
Encorafenib
BRAF inhibitor
|
Encorafenib (NVP-LGX818, LGX818) a potent, selective BRAF inhibitor with IC50 of 0.35, 0.47, and 0.3 nM against BRAF V600E, wild-type BRAF and CRAF in vitro cell-free assays, respectively. |
| PC-73450 |
AZ-628
pan-RAF inhibitor
|
AZ628 (AZD-628) is a potent, selective, pan-RAF kinase inhibitor with IC50 of 105, 29 and 34 nM against for wild-type CRAF, BRAF V600E, and c-Raf-1, respectively. |
| PC-73449 |
Tovorafenib
pan-RAF inhibitor
|
Tovorafenib (MLN2480, TAK-580) is potent, selective, brain-penetrant RAF dimer antagonist, inhibits MAP kinase pathway signaling in BRAF-mutant melanoma models. |
| PC-72612 |
PF-07284890
BRAF V600 mutants inhibitor
|
Tinlorafenib (PF-07284890, ARRY-461) is an orally bioavailable, brain penetrant, potent, small molecule BRAF V600 mutants inhibitor, inhibits BRAF and CRAF with IC50 of 5.8 and 4.1 nM, respectively. |
| PC-72530 |
TAK-632
pan-RAF inhibitor
|
TAK-632 (TAK632) is a potent, selective pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAF V600E and BRAF WT, respectively. |
| PC-72469 |
GNE-9815
pan-RAF inhibitor
|
GNE-9815 (GNE9815) is a potent, selective, oral Type II pan-RAF inhibitor with Ki of 0.062 and 0.19 nM for CRAF and BRAF, respectively. |
| PC-72243 |
BRAF inhibitor Compound Ia
BRAF inhibitor
|
BRAF inhibitor Compound Ia is a potent, selective, brain penetrant BRAF inhibitor with binding Kd of 0.6, 1.2, and 1.7 nM for BRAF WT, BRAF V600E, and c-RAF, presenting paradox breaker properties. |
