| Cat. No. |
Product Name |
Information |
| PC-42482 |
BRAF inhibitor X
RAF inhibitor
|
BRAF inhibitor X is a potent Raf inhibitor, extracted from WO2012006552A1 compound P-0850. |
| PC-45573 |
BGB-283
RAF inhibitor
|
BGB-283 (Lifirafenib, BGB283) is a potent pan RAF inhibitor of BRAF V600E, wt BRAF, CRAFY340/341D and wt ARAF (IC50=5-40 nM). |
| PC-45918 |
PLX-4720
B-Raf V600E inhibitor
|
PLX-4720 (PLX4720 ) is a potent and selective inhibitor of B-Raf V600E with IC50 of 13 nM. |
| PC-45877 |
GDC-0879
B-Raf inhibitor
|
A potent and selective B-Raf kinase inhibitor with IC50 of 0.13 nM against purified B-Raf V600E and a cellular pERK IC50 of 63 nM in the MALME-3M cell line. |
| PC-42755 |
SB-590885
B-Raf inhibitor
|
SB-590885 is a potent and selective B-Raf inhibitor with Kd of 0.3 nM, >1000 fold selectivity over p38a, GSK3b and Lck. |
| PC-45594 |
PLX7904
B-Raf inhibitor
|
PLX7904 is a potent and selective B-Raf inhibitor with IC50 of 5 nM against BRaf V600E in mutant RAS expressing cells. |
| PC-42182 |
RAF709
RAF inhibitor
|
RAF709 is a potent, selective, and orally bioavailable RAF inhibitor with biochemical IC50 of 0.4 nM and 0.5 nM for BRAF and CRAF, respectively. |
| PC-45437 |
RAF-IN-10n
BRAF/CRAF inhibitor
|
RAF-IN-10n is a highlt potent and selective BRAF/CRAF inhibitor with IC50 of 24/25 nM, respectively. |
| PC-21593 |
Erianin
Raf-MEK inhibitor
|
Erianin is a small molecule inhibitor of CRAF and MEK1/2 kinases, inhibits constitutive activation of MAPK signaling pathway. |
| PC-21592 |
SHR902275
RAFinhibitor
|
SHR902275 is a potent, selective, and orally active RAF inhibitor targeting RAS mutants with IC50 of 1.6 nM, 10 nM, and 5.7 nM for cRAF, bRAFwt, and bRAFV600E, respectively. |
