GW 5074 |CAS:220904-83-6 Probechem Biochemicals

Chemical Structure : GW 5074

CAS No.: 220904-83-6

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GW 5074 (10O5, GW-5074, GW5074)

货号: PC-42645Not For Human Use, Lab Use Only.

GW 5074 (10O5) is a potent, selective c-Raf inhibitor with IC50 of 9 nM, also is a alkenyl oxindole molecular glue that tether mHTT to LC3 (Kd=467 nM), enabling the lysosomal degradation of mHTT.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

GW 5074 (10O5) is a potent, selective c-Raf inhibitor with IC50 of 9 nM, also is a alkenyl oxindole molecular glue that tether mHTT to LC3 (Kd=467 nM), enabling the lysosomal degradation of mHTT.
GW 5074 shows >1000-fold selectivity for raf kinase versus CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2, and c-Fms.

物理化学性质&存储条件

分子量	520.942
分子式	C15H8Br2INO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-

参考文献

1. Lackey K, et al. Bioorg Med Chem Lett. 2000 Feb 7;10(3):223-6.

2. Yue X, et al. Eur J Pharmacol. 2006 Jul 1;540(1-3):57-9.

3. Jensen HA, et al. Cell Signal. 2015 Aug;27(8):1666-75.

4. Li Z, et al. Nature. 2019 Nov;575(7781):203-209.

GW 5074 (10O5, GW-5074, GW5074)

生物&药学活性

物理化学性质&存储条件

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GW 5074 (10O5, GW-5074, GW5074)

生物&药学活性

物理化学性质&存储条件

参考文献

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