| Cat. No. |
Product Name |
Information |
| PC-24643 |
T1742
ATG5 inhibitor, Autophagy inhibitor
|
T1742 is a small molecule ATG5 inhibitor, blocks the ATG5-ATG16L1 and ATG5-TECAIR interactions in vitro (IC50=1-2 uM), effectively inhibits autophagy in living cells. |
| PC-20824 |
ATG12-ATG3 inhibitor 189
ATG12-ATG3 inhibitor
|
ATG12-ATG3 inhibitor 189 (Compound 189) is a selective inhibitor of autophagy targeting ATG12-ATG3 protein-protein interaction with IC50 of 9.3 uM. |
| PC-20716 |
DC-ATG4in
ATG4B inhibitor
|
DC-ATG4in is a small molecule autophagy related 4B (ATG4B) inhibitor, directly binds to ATG4B and inhibits its enzyme activity with IC50 of 3.08 uM, DC-ATG4in is an autophagy inhibitor. |
| PC-72137 |
Atg4B inhibitor 21f
ATG4B inhibitor
|
Atg4B inhibitor 21f is a potent competitive inhibitor for Atg4B with Ki of 3.1 uM. |
| PC-72136 |
UAMC-2526
ATG4B inhibitor
|
UAMC-2526 (UAMC2526) is a low micromolar ATG4B and autophagy inhibitor. |
| PC-35632 |
S130
ATG4B inhibitor
|
S130 (ATG4B inhibitor S130) is a potent, specific ATG4B inhibitor with IC50 of 3.24 uM, shows strong affinity (Kd=4 uM) and specifically suppresses the activity of ATG4B, but not other proteases. |
| PC-35540 |
LV-320
ATG4B inhibitor
|
LV-320 (LV320) is a novel potent, cell-active, allosteric inhibitor of the autophagy-related cysteine protease ATG4B with IC50 of 24.5 uM in ATG4B cleavage assays. |
| PC-60598 |
NSC 377071
ATG4B inhibitor
|
NSC 377071 (NSC-377071, NSC377071, Cambendazole) is a novel ATG4B antagonist that inhibits autophagy, with no effect on mTOR and PI3K activities. |
| PC-60597 |
NSC 185058
ATG4B inhibitor
|
NSC 185058 (NSC185058, 2-Pyridinecarbothioamide) is a novel ATG4B antagonist that inhibits autophagy with IC50 of 50 uM, with no effect on mTOR and PI3K activities. |
| PC-42186 |
FMK-9a
ATG4B inhibitor
|
FMK-9a (FMK 9a) is a potent, selective, covalent peptidomimetic inhibitor of ATG4B (Autophagin-1) with IC50 of 80 nM in TR-FRET assay. |
| PC-26069 |
Flubendazole
ATG4B inhibitor
|
Flubendazole is an anthelmintic drug and inhibitor of tubulin polymerization and disruption of microtubule function, also activates ATG4B, induces apoptosis in human colorectal cancer (CRC) by blocking the STAT3 signaling axis and activation of autophagy. |
| PC-26068 |
MJO445
ATG4B inhibitor
|
MJO445 is a small molecule ATG4B inhibitor with IC50 of 12.7 uM, inhibits ATG4B-induced conversion of LC3-I (uncleaved human ATG8) to cleaved and lipidated LC3-II and the degradation of autophagy substrate p62/SQSTM1 p62. |
