ATG4B inhibitor a25

Chemical Structure : ATG4B inhibitor a25

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货号: PC-27272Not For Human Use, Lab Use Only.

ATG4B inhibitor a25 is a small-molecule inhibitor of ATG4B with binding KD of 18.01 nM, modulates autophagy in esophageal squamous cell carcinoma (ESCC).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ATG4B inhibitor a25 is a small-molecule inhibitor of ATG4B with binding KD of 18.01 nM, modulates autophagy in esophageal squamous cell carcinoma (ESCC).
ATG4B inhibitor a25 effectively blocks autophagic flux, decreasesLC3-II levels and increased p62 accumulation.
ATG4B inhibitor a25 inhibits the proliferation of ESCC cells with IC50 of 5 uM.
ATG4B inhibitor a25 suppresses ESCC tumor growth in vivo with no obvious toxicity.

物理化学性质&存储条件

分子量	587.66
分子式	C30H32F3N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	butyl 3-(((4-sulfamoylphenethyl)amino)methyl)-1-(4-(trifluoromethyl)benzyl)-1H-indole-2-carboxylate

参考文献

1. Wenke Jin, et al. Bioorg Chem. 2026 Jun 28:180:110185.