LRRK2 (inhibitors, antagonists, agonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-22144	PF-06447475 LRRK2 inhibitor	PF-06447475 is a highly potent, selective and brain penetrant LRRK2 inhibitor with IC50 of 3 nM, also inhibits STE20 kinase family MST1/MST2 with IC50 of 22 nM (MST2).
PC-49826	Lu AF58786 LRRK2 inhibitor	Lu AF58786 is a potent and selective LRRK2 inhibitor with IC50 of 12 nM, 19 nM and 93 nM for LRRK2 WT, LRRK2-G2019S and LRRK2-A2016T in cell-based assays, respectively.
PC-49823	LRRK2 inhibitor 25 LRRK2 inhibitor	LRRK2 inhibitor 25 is a potent, selective, CNS-penetrant and ATP competitive LRRK2 inhibitor with biochemical IC50 of 0.9 nM, cellular IC50 of 0.3 nM.
PC-49822	LRRK2 GTP binding inhibitor 68 LRRK2 inhibitor	LRRK2 GTP binding inhibitor 68 is a potent, GTP binding inhibitor of LRRK2 with IC90 of 10 nM, inhibits LRRK2 GTP binding and kinase activities.
PC-49821	FX2149 LRRK2 inhibitor	FX2149 (FX 2149) is a potent, BBB permeable inhibitor of LRRK2 GTP binding activity with IC90 of 10 nM, reduces PD-linked mutant LRRK2 variants (G2019S and R1441C) that bound with GTP.
PC-49302	G2019S-LRRK2 inhibitor 22 G2019S-LRRK2 inhibitor	G2019S-LRRK2 inhibitor 22 is a novel potent, BBB-penetrant, G2019S-LRRK2 selective kinase inhibitor with IC50 of 4.6 nM, >700-fold selectivity over WT LRRK2.
PC-38909	DNL201 LRRK2 inhibitor	DNL201 (GNE0877) is a first-in-class, CNS-penetrant, selective, ATP-competitive, small-molecule LRRK2 kinase inhibitor with IC50 of 3 nM.
PC-72161	G2019S-LRRK2 inhibitor 38 G2019S-LRRK2 inhibitor	G2019S-LRRK2 inhibitor 38 is a potent, selective, brain penetrant G2019S-LRRK2 kinase inhibitor with IC50 of <1 nM, cellular EC50 of 40 nM, >2,000-fold selectivity over WT LRRK2 (cellular EC50>100 uM).
PC-72160	EB-42486 G2019S-LRRK2 inhibitor	EB-42486 is a potent, selective G2019S-LRRK2 kinase inhibitor with IC50 of 3.1 nM (pS935-LRRK2) in FRET-based assay, >300-fold selective over WT-LRRR2.
PC-43416	GSK2578215A LRRK2 inhibitor	GSK2578215A is a highly potent, selective, BBB-permeable LRRK2 inhibitor with IC50 of 10.9 and 9.9 nM for wild-type LRRK2 and the G2019S mutant, respectively.
PC-42945	GNE-9605 LRRK2 inhibitor	GNE-9605 is a highly potent, selective, brain penetrant LRRK2 inhibitor with Ki of 2 nM, pLRRK2 IC50 of 19 nM.
PC-62508	PFE-360 LRRK2 inhibitor	PFE-360 (PF-06685360) is a potent, selective, brain-penetrating LRRK2 inhibitor with IC50 of 3 nM.

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