| Cat. No. |
Product Name |
Information |
| PC-22377 |
3-TYP
SIRT3 inhibitor
|
3-TYP is a specfiic small molecule inhibitor of Sirtuin 3 (SIRT3) with IC50 of 38 uM, selectively inhibits Sirt3 over Sirt1 and Sirt2 and is more potent than nicotinamid. |
| PC-21990 |
SIRT6 inhibitor 11e
SIRT6 inhibitor
|
SIRT6 inhibitor 11e (Compound 11e) is a potent, selective and allosteric SIRT6 inhibitor with IC50 of 0.98 uM, directly binds to SIRT6 with Kd of 9.46 uM, inhibits pancreatic cancer metastasis in vitro and vivo. |
| PC-21165 |
EX-527
SirT1 inhibitor
|
Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with IC50 of 123 nM for SirT1. |
| PC-20271 |
40569Z
SIRT7 inhibitor
|
40569Z is a specific SIRT7 inhibitor, significantly inhibits SIRT7 deacetylation activity without effects on SIRT1 and SIRT6 activities, induces apoptosis and increases chemosensitivity to sorafenib in human liver cancer. |
| PC-20270 |
2800Z
SIRT7 inhibitor
|
2800Z is a specific SIRT7 inhibitor, significantly inhibits SIRT7 deacetylation activity without effects on SIRT1 and SIRT6 activities, induces apoptosis and increases chemosensitivity to sorafenib in human liver cancer. |
| PC-20269 |
MDL-811
SIRT6 activator
|
MDL-811 (MDL811) is a potent, selective and allosteric SIRT6 activator with EC50 of 5.7 uM (activated SIRT6 deacetylation), two-fold greater activity than MDL-800 (EC50=12.3 uM, Cat# 35760). |
| PC-49474 |
SCIC2.1
SIRT1 activator
|
SCIC2.1 is a potent small molecule SIRT1 activator (175%, AC50=36.8 uM), directly binds SIRT1 and protects SIRT1 from thermal degradation. |
| PC-49248 |
JYQ-42
SIRT6 inhibitor
|
JYQ-42 is a potent, selective SIRT6 allosteric inhibitor, effectively inhibits SIRT6 deacetylation with IC50 of 2.33 uM, inhibits the deacetylation activity of SIRT6 in pancreatic cancer cell lines. |
| PC-49081 |
MC3138
SIRT5 activator
|
MC3138 is a potent and selective small-molecule SIRT5 activator, inhibits proliferation in SIRT5-low PDAC cell lines and organoids. |
| PC-47061 |
SRT2104
SIRT1 activator
|
SRT2104 (GSK2245840) is a highly selective small molecule activator of the NAD+ dependent deacetylase SIRT1. |
| PC-38584 |
SIRT6 activator 12q
SIRT6 activator
|
SIRT6 activator 12q (Compound 12q) is a potent, selective SIRT6 activator with EC1.5 value of 0.58 μM and EC50 value of 5.35 μM against SIRT6-dependent peptide deacetylation in FLUOR DE LYS assay. |
| PC-38580 |
SIRT6 activator CL5D
SIRT6 activator
|
SIRT6 activator CL5D is a novel small-molecule activator of SIRT6 deacetylation, stimulates 4-fold activation of SIRT6 (1 uM) against H3K9ac (20 uM) at 3 uM. |
