| Cat. No. |
Product Name |
Information |
| PC-21202 |
KME-3859
IRAK4 inhibitor
|
KME-3859 is a potent, selective IRAK4 inhibitor with IC50 of 5 nM, 100-fold selective over IRAK1. |
| PC-21201 |
KME-2780
IRAK1/4 inhibitor
|
KME-2780 (KME2780) is a potent and selective dual IRAK1 and IRAK4 (IRAK1/4) inhibitor with IC50 of 19 and 0.5 nM, respectively. |
| PC-49845 |
GLPG2534
IRAK4 inhibitor
|
GLPG2534 (GLPG 2534) is a potent, selective IRAK4 inhibitor with therapeutic potential in chronic inflammatory skin diseases. |
| PC-49046 |
ND-2110
IRAK4 inhibitor
|
ND2110 is a highly selective and bioavailable small molecule IRAK4 inhibitor with IC50 of 7.5 nM, no significant activity against IRAK1 (IC50>2000 nM). |
| PC-38684 |
BAY1830839
IRAK4 inhibitor
|
BAY1830839 is a potent, selective IRAK4 inhibitor with IC50 of 3.0 nM, inhibits IRAK4 mediated activation of the TLR/MYD88 pathway. |
| PC-38683 |
Zabedosertib
IRAK4 inhibitor
|
Zabedosertib (BAY1834845) is a potent, selective IRAK4 inhibitor with IC50 of 3.4 nM, inhibits IRAK4 mediated activation of the TLR/MYD88 pathway. |
| PC-73131 |
HS-243
IRAK1/4 inhibitor
|
HS-243 (HS243) is a highly potent, super-selective IRAK-1/4 inhibitor with IC50 of 24/20 nM, respectively. |
| PC-72011 |
GNE-2256
IRAK4 inhibitor
|
GNE-2256 (GNE2256) is a potent, selective inhibitor of IRAK4 with biochemical Ki of 1.4 nM. |
| PC-38157 |
ND2158
IRAK4 inhibitor
|
ND2158 (ND-2158) is a highly potent and selective IRAK4 inhibitor with IC50 of 1.3 nM. |
| PC-38076 |
THZ-2-118
IRAK1 inhibitor
|
THZ-2-118 is a potent selective inhibitor of IRAK1 with IC50 of 14.2 nM. |
| PC-38073 |
JH-X-119-01
IRAK1 inhibitor
|
JH-X-119-01 is a highly potent, selective and covalent inhibitor of IRAK1 with IC50 of 9 nM. |
| PC-36036 |
HG-12-6
IRAK4 inhibitor
|
HG-12-6 is a small-molecule inhibitor that bind preferentially to unphosphorylated IRAK4 with IC50 of 165.1 nM, displays 15-fold selectivity over phosphorylated IRAK4 (IC50=2876 nM). |
