| Cat. No. |
Product Name |
Information |
| PC-28721 |
HLI373 dihydrochloride
Hdm2 inhibitor
|
HLI373 dihydrochloride is a small molecule ubiquitin ligase (E3) Hdm2 inhibitor, stabilizes Hdm2 and p53, activating p53-dependent transcription, and inducing cell death, induces apoptosis of tumor cells lines that is sensitive to DNA-damaging agents. |
| PC-28720 |
HLI373
Hdm2 inhibitor
|
HLI373 is a small molecule ubiquitin ligase (E3) Hdm2 inhibitor, stabilizes Hdm2 and p53, activating p53-dependent transcription, and inducing cell death, induces apoptosis of tumor cells lines that is sensitive to DNA-damaging agents. |
| PC-28029 |
RVJB59
p53 activator
|
RVJB59 is a covalent small molecule activator of wtP53 and p53 mutants, shows selective covalent binding to Cys 141 of wt p53DBD. |
| PC-25767 |
PhiKan083
p53 Y220C reactivator
|
PhiKan083 (PhiKan 083) is a specific reactivator and stabilizer and reactivator of p53 Y220C mutant with dissociation constant of 150 uM, binds to the surface cavity and stabilizes p53 Y220C.. |
| PC-25763 |
PK5196
p53 Y220C reactivator
|
PK5196 is a small molecule p53 Y220C reactivator and p53 Y220C binder (SPR Kd=6.88 uM), effectively increase the thermal stability of p53 Y220C protein. |
| PC-25659 |
p53 Y220C activator KG13
p53 Y220C reactivator
|
p53 Y220C activator KG13 is a allele-specific covalent small molecule that selectively reacts with the mutant cysteine Y220C of p53 (p53 Y220C), rescues wild-type thermal stability and gene activation. |
| PC-25429 |
Idasanutlin
p53-MDM2 inhibitor
|
Idasanutlin (RG7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM in HTRF binding assays, inhibits wt-p53 cancer cell lines (SJSA1, RKO, HCT116) with mean IC50 of 0.03 uM. |
| PC-23521 |
TRAP-1
p53 activator
|
TRAP-1 is a small molecule chemical inducer of proximity that activates mutant p53, engages mutant p53Y220C and BRD4 in a ternary complex, which potently activates mutant p53 and triggers robust p53 target gene transcription. |
| PC-23083 |
Rezatapopt
p53 Y220C reactivator
|
Rezatapopt (PC14586) is a first-in-class, orally bioavailable Y220C mutant p53 reactivator, binds to the pocket created by the TP53 Y220C mutation (KD=2.5 nM), restoring p53 function. |
| PC-22247 |
Pifithrin-α hydrobromide
p53 inhibitor
|
Pifithrin-α hydrobromide is a small molecule inhibitor of p53, blocks its transcriptional activity and prevents cells from apoptosis, also is an aryl hydrocarbon receptor (AhR) agonist. |
| PC-21746 |
NSC146109
MDMX inhibitor, p53 activator
|
NSC146109 (XI-011) is a small-molecule p53 activator, induces apoptosis of breast cancer cells through inhibiting MDMX (MDM4) expression. |
| PC-20688 |
MMRi71
MDM2-MDM4 E3 ligase inhibitor
|
MMRi71 is a small molecule inhibitor of the E3 ligase activity of MDM2-MDM4, and an inducer of MDM4 and FTH1 dual protein degradation and p53-independent apoptosis in leukemia cells. |
