| Cat. No. |
Product Name |
Information |
| PC-23083 |
PC14586
p53 Y220C reactivator
|
Rezatapopt (PC14586) is a first-in-class, orally bioavailable Y220C mutant p53 reactivator, binds to the pocket created by the TP53 Y220C mutation (KD=2.5 nM), restoring p53 function. |
| PC-20668 |
Brigimadlin
MDM2-p53 antagonist
|
BI 907828 ( Brigimadlin) is an orally available inhibitor of murine double minute 2 (MDM2) with potential antineoplastic activity, BI 907828 binds to MDM2 protein and prevents its binding to p53. |
| PC-20010 |
J012-3168
RPL11-MDM2 inhibitor
|
RPL11-MDM2 inhibitor S9 (J012-3168) is a small-molecule RPL11 mimetic and potential inhibitor of RPL11-MDM2 interaction, directly binds MDM2 and induces p53 stabilization and activation. |
| PC-49577 |
K-181
Mdmx-p53 inhibitor
|
K-181 is a specific small-molecule Protein-Protein Interaction (PPI) inhibitor of Mdmx-p53 interaction, exhibits neuroprotective effects on ischemic stroke by disrupting Mdmx-p53 interaction and inhibiting HDAC6 activity. |
| PC-49512 |
GY1-22
DNAJA1-mutp53R175H inhibitor
|
GY1-22 is a small molecule inhibitor against DNAJA1-mutP53R175H interacting pocket, reduces mutp53 protein expression in colon cancer cell line with p53R175H mutation. |
| PC-49493 |
UC2288
p21 inhibitor
|
UC2288 is a small molecule p21 inhibitor, attenuates p21 protein abundance at 10 µM, independently of p53 activity and at the level of transcription or post-transcription. |
| PC-49217 |
UCI-LC0019
mutant p53 reactivator
|
UCI-LC0019 is a specific small molecule that restores mutant p53 activity by targeting the cryptic L1/S3 pocket of p53, directly binds to mutant p53 and restores wild-type-like conformation of mutant p53R175H. |
| PC-49216 |
UCI-LC0023
mutant p53 reactivator
|
UCI-LC0023 is a small molecule that restores mutant p53 activity by targeting the cryptic L1/S3 pocket of p53, directly binds to mutant p53 and restores wild-type-like conformation of mutant p53R175H. |
| PC-49198 |
Morncide
p53-Morn3 inhibitor
|
Morncide (Morn3 (222-237)) is a cell-penetrating, 16-AA Morn3-targeting peptide that disrupts the interaction between p53 and Morn3-mediated complex, Morncide peptide stabilizes and reactivates p53 in cancer cells. |
| PC-49087 |
BAY 249716
p53 modulator
|
BAY 249716 is a small molecule that modulate mutant p53 condensation, showed significant stabilization of all three p53 protein variants, p53WT p53R175H and p53Y220C. |
| PC-49086 |
BAY 1892005
p53 modulator
|
BAY 1892005 is a small molecule that modulate mutant p53 condensation and nuclear accumulation, binds covalently to mutant p53R175H and p53Y220C and shows stabilization of p53WT and p53Y220C, exhibits anti-proliferative activity in a set of cell lines with different p53 mutation status with low-uM IC50 values. |
| PC-38473 |
Inauhzin
p53 activator, SIRT1 inhibitor
|
Inauhzin (INZ) is a small molecule SIRT1 inhibitor that effectively reactivates p53, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. |
