MMRi71

Chemical Structure : MMRi71

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货号: PC-20688Not For Human Use, Lab Use Only.

MMRi71 is a small molecule inhibitor of the E3 ligase activity of MDM2-MDM4, and an inducer of MDM4 and FTH1 dual protein degradation and p53-independent apoptosis in leukemia cells.

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生物&药学活性

MMRi71 is a small molecule inhibitor of the E3 ligase activity of MDM2-MDM4, and an inducer of MDM4 and FTH1 dual protein degradation and p53-independent apoptosis in leukemia cells.
MMRi71 exhibits anti-proliferation effect against the wtp53-bearing NALM6 (p53-dependent) and shP53NALM6 (p53-independent) leukemia cell lines with IC50 of 0.23 and 0.29 uM, respectively.
MMRi71 shows strong anti-leukemic activity in the cell proliferation inhibitory assay along with the dose-dependent inhibition of MDM2B E3 ligase activity.
MMRi71 induces MDM2-dependent proteasomal degradation of MDM4 and the lysosome-dependent degradation of FTH1.
MMRi71 effectively kills p53-null leukemia cells, an activity that conventional MDM2-p53 disrupting inhibitors lack.

物理化学性质&存储条件

分子量	490.94
分子式	C26H23ClN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(OCC)C1=CC=C(C(C2=CC(Cl)=C3C=CC=NC3=C2OC(CC)=O)NC4=NC=CC=N4)C=C1

参考文献

1. Rati Lama, et al. Molecules. 2022 Nov 8;27(22):7665.

MMRi71

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物理化学性质&存储条件

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MMRi71

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