| Cat. No. |
Product Name |
Information |
| PC-49525 |
Fam20C inhibitor 3r
Fam20C inhibitor
|
Fam20C inhibitor 3r is a novel small-molecule inhibitor of Fam20C that induces apoptosis and inhibits migration in triple negative breast cancer. |
| PC-49524 |
FL-1607
Fam20C inhibitor
|
FL-1607 is a novel Fam20C inhibitor with potent anti-proliferative effects on TNBC cells, induces apoptosis and inhibits migration in MDA-MB-468 cells. |
| PC-49496 |
PF670462
CK1ε/CK1δ inhibitor
|
PF-670462 (PF670462) is a potent and selective inhibitor casein kinase CK1ε and CK1δ with IC50 of 7.7 nM and 14 nM, respectively, causes a significant phase delay in animal models of circadian rhythm. |
| PC-38526 |
Epiblastin A
CK1 inhibitor
|
Epiblastin A is a small molecule ATP-competitive casein kinases 1 (CK1) inhibitor with IC50 values of 0.8, 3.7 and 3.8 uM for CK1δ, CK1ε and CK1α, engages CK1 isoenzymes in cell lysate and induces efficient conversion of mouse epiblast stem cells (EpiSCs) to embryonic stem cells (cESCs). |
| PC-72809 |
SGC-CK2-1
CK2 inhibitor
|
SGC-CK2-1 is a potent, selective, cell active ATP-competitive inhibitor of host protein kinase Casein Kinase 2 (CSNK2/CK2, pIC50=8.3), inhibits the pathogenic β-coronaviruses including SARS-CoV-2 (MHV pIC50=6.9). |
| PC-72647 |
Multikinase inhibitor 108600
Multikinase inhibitor
|
Multikinase inhibitor 108600 (108600) is a novel multi-kinase inhibitor and inhibitor of TNBC growth (GI50=0.12-0.75 uM), inhibits CK2α1/α2, DYRK1A, 1B, and DYRK2 and TNIK (IC50=5-50 nM). |
| PC-72228 |
CK2 inhibitor KN2
CK2 inhibitor
|
CK2 inhibitor KN2 is a potent, highly selective, cell-permeable, bivalent CK2 inhibitor, binds to CK2α- and CK2α′-based CK2 holoenzymes with Ki of 6.1 nM (CK2α2β2) and 4.0 nM (CK2α′2β2). |
| PC-72167 |
CIGB-300
CK2 inhibitor
|
CIGB-300 (P15-Tat) is a cell-permeable cyclic peptide that modulates CK2 (CSNK2) activity by binding to the phosphoacceptor site on CK2 targets, abrogates the CK2 phosphorylation by blocking recombinant substrates in vitro. |
| PC-36054 |
ON108110
CK2 inhibitor, CDK4/6 inhibitor
|
ON108110 (ON-108110, ON 108110) is a novel multi-kinase inhibitor of protein kinase CK2 (CK2α1/2, IC50=3/2 nM) as well as CDK4/6 (IC50=2-24 nM). |
| PC-36021 |
GO289
CK2 inhibitor
|
GO289 (GO-289, GO 289) is a potent and selective inhibitor of casein kinase 2 (CK2) with IC50 of 7 nM in in vitro kinase assays, shows minor effects on CKIδ and CKIα activity in vitro. |
| PC-35629 |
BTX161
CK1α degrader
|
BTX161 is a thalidomide analog that mediates degradation of CKIα better than lenalidomide in human AML cells and activates DDR and p53, while stabilizing the p53 antagonist MDM2. |
| PC-35628 |
Casein Kinase inhibitor A86
CK1α inhibitor, CDK7/9 inhibitor
|
Casein Kinase inhibitor A86 (CK1α inhibitor A86) is a novel pan-specific CK1 (CSNK1) inhibitor (Kd=1-10 nM, CK1α Kd=9.8 nM) that co-targets the transcriptional kinases CDK7 and CDK9, with hardly inhibition of CDK8, CDK13, CDK11a, CDK11b, and CDK19. |
