PC-23746 |
BRD0539
SpCas9 inhibitor
|
BRD0539 is a cell-permeable, reversible inhibitor of Streptococcus pyogenes Cas9 (SpCas9) with IC50 of 22 uM in vitro DNA cleavage assays, effectively inhibits the DNA-binding ability of SpCas9 by disrupting the interaction between SpCas9 and the protospacer adjacent motif (PAM). |