| Cat. No. |
Product Name |
Information |
| PC-22920 |
AB25583
Polθ helicase inhibitor
|
AB25583 is a potent, specific small molecule inhibitor of SF2 DNA helicase domain of Polθ (Polθ-hel) with IC50 of 6 nM in Polθ-hel ATPase activity assay, selectively kills BRCA-deficient cells. |
| PC-22778 |
SCR7 pyrazine
DNA Ligase IV inhibitor
|
SCR7 pyrazine is a stable oxidized form of SCR7 and specific DNA Ligase IV inhibitor, inhibits nonhomologous end-joining (NHEJ) and induces cancer cell death. |
| PC-22070 |
RTx-161
DNA Polθ inhibitor
|
RTx-161 (RTx161) is a potent, selective, allosteric DNA Polymerase θ (Polθ) inhibitor with IC50 of 4.1 nM, exhibits preferential killing of HR-deficient cells. |
| PC-49690 |
Novobiocin
POLθ inhibitor
|
Novobiocin (NVB) is a potent, specific DNA polymerase theta (POLθ, POLQ) inhibitor with IC50 of 24 uM, selectively kills HR-deficient tumor cells in vitro and in vivo. |
| PC-49680 |
ART899
DNA Polθ inhibitor
|
ART899 (ART-899) is a potent, specific allosteric inhibitor of DNA polymerase theta (Polθ), specifically inhibits Polθ MMEJ activity with IC50 of 180 nM, shows with improved in vivo stability compared to ART558. |
| PC-49362 |
ART812
DNA Polθ inhibitor
|
ART812 (ART-812) is a selective small molecule DNA polymerase theta (Polθ) in vivo probe with IC50 of 7.6 nM, and IC50 of 240 nM for cell based microhomology-mediated end joining (MMEJ). |
| PC-49348 |
RP-6685
DNA Polθ inhibitor
|
RP-6685 (RP6685) is a potent, selective and orally bioavailable inhibitor of DNA polymerase theta (Polθ) with IC50 of 5.8 nM in PicoGreen assay (0.3 nM Polθ enzyme). |
| PC-38616 |
Lurbinectedin
DNA covalent binder
|
Lurbinectedin (PM01183) is a marine-derived DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity, inhibits RMG1 and RMG2 cell growth with IC50 of 1.25 nM and 1.16 nM, respectively. |
| PC-38571 |
L189
DNA ligase inhibitor
|
L189 is a small moelcule DNA ligase I, III and IV inhibitor with IC50 of 5, 9 and 5 uM, blocks DNA ligase I DNA binding activity with Ki of 5 uM. |
| PC-38570 |
L82-G17
DNA ligase I inhibitor
|
L82-G17 is a selective, uncompetitive inhibitor of DNA ligase I, inhibits the third step of the ligation reaction, phosphodiester bond formation. |
| PC-73404 |
Bersiporocin
PRS inhibitor
|
Bersiporocin (DWN 12088) is an orally administered small molecule prolyl-tRNA synthetase (PRS) inhibitor with antifibrotic effect. |
| PC-73357 |
Pyridostatin
G-quadruplex stabilizer
|
Pyridostatin (RR82) is a high-affinity G-quadruplex-stabilizing small molecule (Kd=490 nM), promotes the folding of telomeric G-quadruplexes, induces DNA damage and cell cycle arrest. |
