YH-0623 | POLRMT inhibitor | Probechem Biochemicals

Chemical Structure : YH-0623

加入收藏

YH-0623 (YH0623)

货号: PC-25138Not For Human Use, Lab Use Only.

YH-0623 is a potent, selective mitochondrial RNA polymerase (POLRMT) inhibitor with IC50 of 45 nM on the 22Rv1 cell line, significantly reduces the ND1 mitochondrial factor to 14%, demonstrating 1.5-fold greater activity than IMT1B.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

YH-0623 is a potent, selective mitochondrial RNA polymerase (POLRMT) inhibitor with IC50 of 45 nM on the 22Rv1 cell line, significantly reduces the ND1 mitochondrial factor to 14%, demonstrating 1.5-fold greater activity than IMT1B.
YH-0623 selectively reduced the expression of mitochondrial genes ND1, CytB, and COX1, while transcripts mediated by nuclear RNA polymerases I, II, and III remained unaffected.
YH-0623 induced a dose-dependent downregulation of specific subunits of respiratory chain complexes encoded by mtDNA, including NDUFB8 (complex I), UQCRC2 (complex III), and COX1 (complex IV).
YH-0623 significantly stabilized POLRMT, specifically targets mitochondrial transcription through POLRMT inhibition.
YH-0623 suppresses mitochondrial-related gene expression by inhibiting mitochondrial transcription.
YH-0623 effectively suppresses 22Rv1 cell proliferation in a concentration-dependent manner.
YH-0623 inhibits cell proliferation through a nonapoptotic and cell cycle-independent mechanism.
YH-0623 inhibits mitochondrial function primarily by suppressing OXPHOS without significantly altering MMP, ROS levels, or glycolytic activity.
YH-0623 (50 mg/kg per day) suppressed 22Rv1 cell xenograft growth in vivo.

物理化学性质&存储条件

分子量	436.48
分子式	C25H25FN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-((R)-2-((6-Fluoro-4-(O-tolyl)quinolin-7-yl)oxy)propanoyl)piperidine-3-carboxylic Acid

参考文献

1. Li X, et al. J Med Chem. 2025 Jul 29. doi: 10.1021/acs.jmedchem.5c00130.

YH-0623 (YH0623)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

YH-0623 (YH0623)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.