| Cat. No. |
Product Name |
Information |
| PC-20485 |
BAR502
Dual FXR/GPBAR1 agonist
|
BAR502 (NorECDCOH) is a potent, selective, dual farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1, TGR5) ligand (agonist) with EC50 of 2.0 and 0.4 uM, respectively. |
| PC-20484 |
PDL103
Dual FXR/GPBAR1 antagonist
|
PDL103 is a potent, dual FXR/GPBAR1 antagonist with IC50 of 10 and 19 uM, respectively. |
| PC-47028 |
BMS-986339
FXR agonist
|
BMS-986339 is a potent, selective farnesoid X receptor (FXR) agonist with EC50 of 34 nM (hFXR-Gal4), demonstrates differential induction of Fgf15 in the liver and ileum by FXR agonists in vivo. |
| PC-38044 |
EDP-305
FXR agonist
|
EDP-305 (EDP305) is a potent, selective, nonbile acid farnesoid X receptor (FXR) agonist with EC50 of 34 nM, shows antifibrotic effect. |
| PC-43034 |
INT-767
FXR/TGR5 agonist
|
INT-767 (INT767) is a potent, selective, dual farnesoid X receptor (FXR) and TGR5 agonist with EC50 of 30 and 630 nM, respectively. |
| PC-63021 |
MFA-1
FXR agonist
|
MFA-1 (Merck FXR agonist 1) is a potent, synthetic FXR agonist with EC50 of 16.9 nM in coactivator recruitment assays, displays 500-fold more potent than CDCA. |
| PC-61390 |
Nidufexor
FXR agonist
|
Nidufexor (LMB763, LMB-763) is a potent, selective, non-bile acid partial agonist of farnesoid X receptor (FXR) with EC50 of 7 nM in FXR-HTRF biochemical assay measuring the ligand-induced interaction between FXR and the Steroid Receptor Coactivator-1 (SRC1). |
| PC-61368 |
Cilofexor
FXR agonist
|
Cilofexor (GS-9674, GS9674, PX-104) is a potent, specific, non-steroidal farnesoid X receptor (FXR) agonist with EC50 of 43 nM. |
| PC-61057 |
DM509
FXR agonist, sEH inhibitor
|
DM509 is a potent, orally active dual modulator of FXR and soluble epoxide hydrolase (sEH) that exertss partial FXR agonism (pEC50=7.7) and sEH inhibitory activity (pIC50=8.4). |
| PC-60080 |
GSK2324
FXR agonist
|
GSK2324 (GSK 2324) is a potent, selective, full FXR agonist with EC50 of 120 nM in FRET assay. |
| PC-60079 |
LY2562175
FXR agonist
|
LY2562175 (TERN-101) is a novel potent, selective, partial FXR agonist with EC50 of 193 nM. |
| PC-60056 |
Tropifexor
FXR agonist
|
Tropifexor (LJN-452, LJN452) is a novel highly potent, selective, orally acitive FXR full agonist with EC50 of 0.26 nM. |
