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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Farnesoid X Receptor (FXR)-EDP-305
EDP-305

Chemical Structure : EDP-305

CAS No.: 1933507-63-1

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EDP-305 (EDP305)

货号: PC-38044Not For Human Use, Lab Use Only.

EDP-305 (EDP305) is a potent, selective, nonbile acid farnesoid X receptor (FXR) agonist with EC50 of 34 nM, shows antifibrotic effect.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

EDP-305 (EDP305) is a potent, selective, nonbile acid farnesoid X receptor (FXR) agonist with EC50 of 34 nM, shows antifibrotic effect.
EDP-305 displays antifibrotic effect in rodent models of cholestatic and fatty liver injury: bile duct ligation (BDL) in rats and choline‐deficient, L‐amino acid‐defined, high‐fat diet (CDAHFD) in mice.
EDP‐305 dose‐dependently decreases macrophage infiltration and proinflammatory cytokine gene expression.
EDP‐305 also dose‐dependently reduces interstitial fibrosis and kidney hydroxyproline levels.
EDP‐305 decreases TGF‐β1-induced YAP nuclear localization in human kidney 2 cells by increasing inhibitory YAP phosphorylation.
EDP‐305 reduces interstitial renal fibrosis in a mouse model of unilateral ureteral obstruction.

物理化学性质&存储条件

分子量 630.93
分子式 C36H58N2O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(1,1-Dimethylethyl)-N-[[[(3α,5β,6α,7α)-6-ethyl-3,7-dihydroxy-24-norcholan-23-yl]amino]carbonyl]benzenesulfonamide

参考文献

1. Erstad DJ, et al. Hepatol Commun. 2018 May 21;2(7):821-835.

2. Li S, et al. FASEB J. 2019 Jun;33(6):7103-7112.

3. An P, et al. Liver Int. 2020 Jul;40(7):1655-1669.

4. Ratziu V, et al. J Hepatol. 2022 Mar;76(3):506-517.

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