| Cat. No. |
Product Name |
Information |
| PC-28714 |
Autophagy activator MG-1
Autophagy activator
|
Autophagy activator MG-1 is a bifunctional small molecule autophagy activator / inducer that enhances the removal of damaged mitochondria through autophagy, shows autophagy-inducing activity under conditions of mitochondrial stress. |
| PC-28579 |
LH2-051
TFEB activator, DAT inhibitor
|
LH2-051 is a lysosome-enhancing compound that promote TFEB (transcription factor EB) activation and lysosome biogenesis, significantly inhibits the function of the dopamine transporter (DAT) and subsequently promotes lysosome biogenesis via DAT-CDK9-TFEB axis. |
| PC-28575 |
DCL1191
TFEB inhibitor
|
DCL1191 is a potent, selective and orally bioavailable of transcription factor EB (TFEB) inhibitor with MST Kd of 80.5 nM for TFEB bHLHLZ domain, disrupts the TFEB-DNA interaction with IC50 of 60.5 nM. |
| PC-27710 |
Autophagy activator SQ-1
Autophagy activator, p62 ZZ domain binder
|
Autophagy activator SQ-1 (STOCK1N-57534) is a small-molecule activator of autophagy, engages the prototypical SAR protein p62/SQSTM1 (sequestosome-1), binds ZZ domain of p62 and induces p62 oligomerisation. |
| PC-25750 |
GW296115
BRSK2 inhibitor
|
GW296115 is a potent inhibitor of brain-specific serine/threonine protein kinases BRSK2 with IC50 of 8.4 nM and 21 nM for BRSK2 and BRSK1 respectively. |
| PC-24817 |
CIM7
CMA inhibitor, NCoR1/RARα inhibitor
|
CMA Inhibitory Molecule 7 (CIM7) is a potent and selective chaperone-mediated autophagy (CMA) inhibitor with IC50 of 75 nM (A549 cells, 24h), functions by disrupting the NCoR1/RARα interaction and altering the CMA regulatory transcriptional program to suppress CMA. |
| PC-23449 |
YT-6-2
p62/SQSTM1 agonist
|
YT-6-2 (YT 6-2) is a small molecule p62/SQSTM1 agonist and ligand, binds to the ZZ domain of the autophagic cargo receptor SQSTM1/p62, exerts antimicrobial efficacy. |
| PC-21540 |
RH1115
Autophagy activator
|
RH1115 is a small molecule activator and inducer of autophagy targeting Lamin A/C and LAMP1, induces changes to LAMP1 vesicle properties and alters lysosome positioning. |
| PC-20502 |
JS-017
A2E degrader
|
JS-017 (JS017) is a small molecule degrader of N-retinylidene-N-retinylethanolamine (A2E), one of the components of lipofuscin, degrades A2E-BDP from ARPE-19 cells with IC50 of 3.239 uM. |
| PC-49727 |
YTK-2205
p62 agonist, autophagy inducer
|
YTK-2205 (YTK2205) is a small molecule p62 agonist targeting ZZ domain, induces selective autophagy activation, YTK-2205 augments the translocation of p62 to mitochondria, targeting their lysosomal degradation. |
| PC-49174 |
EAD1
Autophagy inhibitor
|
EAD1 is a potent autophagy inhibitor, exhibits growth inhibitory activity in human cancer cell lines, H460 and HCC827 NSCLC and BxPC3 pancreatic cancer cells with IC50 of 11, 7.6, and 5.8 uM, respectively. |
| PC-38562 |
Autophagy inducer D61
Autophagy inducer
|
Autophagy inducer D61 is a small molecule autophagy inducer with antibacterial activity, induces LC3II and promotes aggregation of LC3II near Salmonella. |
