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首页-小分子抑制剂&激动剂-Autophagy-YTK-2205
YTK-2205

Chemical Structure : YTK-2205

CAS No.: 2376852-20-7

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YTK-2205 (YTK2205)

货号: PC-49727Not For Human Use, Lab Use Only.

YTK-2205 (YTK2205) is a small molecule p62 agonist targeting ZZ domain, induces selective autophagy activation, YTK-2205 augments the translocation of p62 to mitochondria, targeting their lysosomal degradation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    YTK-2205 (YTK2205) is a small molecule p62 agonist targeting ZZ domain, induces selective autophagy activation, YTK-2205 augments the translocation of p62 to mitochondria, targeting their lysosomal degradation.
    YTK-2205 (20 mg/kg) exerts therapeutic efficacy in paracetamol-induced liver damage, YTK-2205 successfully induced in vivo p62 oligomerization in livers from paracetamol-treated mice.
    YTK-2205 limits JNK phosphorylation without altering either NRF2 pathway or mitochondrial RIPK1 translocation during paracetamol-induced hepatotoxicity.
    YTK-2205 efficiently reduces ubiquitinated proteins in vivo by promoting selective autophagy, selectively accelerated the autophagic removal of damaged parts of the mitochondrion and ER.
    YTK-2205 promotes p62-mediated ER-phagy and mitophagy in paracetamol-loaded primary murine hepatocytes.

    物理化学性质&存储条件

    分子量 391.51
    分子式 C25H29NO3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((3,4-diphenethoxybenzyl)amino)ethan-1-ol

    参考文献

    1. Hee-Yeon Kim, et al. Br J Pharmacol. 2022 Dec 7. doi: 10.1111/bph.16004.

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