| Cat. No. |
Product Name |
Information |
| PC-20193 |
LY2090314
GSK-3 inhibitor
|
LY2090314 is a potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3) with IC50 of 1.5/0.9 nM for GSK3α/GSK3β, respectively. |
| PC-20191 |
GSK3 inhibitor 117
GSK-3 inhibitor
|
GSK3 inhibitor 117 is a novel selective GSK-3 inhibitor, shows cytotoxicity against AML in vitro and in vivo. |
| PC-20114 |
GSK-3β inhibitor 47
GSK3β inhibitor
|
GSK-3β inhibitor 47 is a potent, selective, brain-penetrant, orally bioavailable GSK-3β inhibitor with IC50 of 0.73 nM, inhibits phosphorylated tau with cell IC50 of 58 nM. |
| PC-49290 |
Tideglusib
GSK-3 inhibitor
|
Tideglusib (NP031112, NP-12) is a potent and irreversible small molecule glycogen synthase kinase 3 (GSK-3) inhibitor with IC50 of 60 nM. |
| PC-49262 |
SB415286
GSK-3 inhibitor
|
SB-415286 (SB415286) is a potent, selective, ATP competitive small molecule inhibitor of GSK-3alpha with Ki of 31 nM, inhibits GSK-3beta with similar potency. |
| PC-38653 |
ARN25068
GSK-3β/FYN/DYRK1A inhibitor
|
ARN25068 is a highly potent, triple GSK-3β/FYN/DYRK1A inhibitor with IC50 of 4.17 and 2.17 μM for GSK-3β and FYN, reduces the extent of tau phosphorylation in Tau0N4R-TM-tGFP U2OS cell line. |
| PC-38527 |
GSK-3 Inhibitor XIII
GSK-3 inhibitor
|
GSK-3 Inhibitor XIII is a potent and ATP-binding site inhibitor of GSK-3. |
| PC-72725 |
COB-187
GSK-3 inhibitor
|
COB-187 (COB187) is a highly potent and selective inhibitor of GSK-3 with IC50 of 22/11 nM against GSK-3α/GSK-3β. |
| PC-63357 |
MMBO
GSK-3 inhibitor
|
MMBO is a potent, highly selective, brain penetrant, orally active inhibitor of GSK-3 with IC50 of 37 and 53 nM for GSK-3α and GSK-3β, respectively. |
| PC-63312 |
BRD3731
GSK3β inhibitor
|
BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM). |
| PC-63311 |
BRD0705
GSK3α inhibitor
|
BRD0705 is a potent, paralog-selective GSK3α inhibitor with IC50 of 66 nM, 8-fold selectivity over GSK3β (IC50=515 nM). |
| PC-63239 |
Methyliodobikinin
GSK3-like kinase BIN2 inhibitor
|
Methyliodobikinin is a potent bikinin-like inhibitor targeting GSK3/Shaggy-like kinase, shows improved cell permeability, highly potent in vivo although it had lower activity in vitro. |
