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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-GSK-3-ARN25068
ARN25068

Chemical Structure : ARN25068

CAS No.: 2649882-80-2

ARN25068 (ARN-25068)

货号: PC-38653Not For Human Use, Lab Use Only.

ARN25068 is a highly potent, triple GSK-3β/FYN/DYRK1A inhibitor with IC50 of 4.17 and 2.17 μM for GSK-3β and FYN, reduces the extent of tau phosphorylation in Tau0N4R-TM-tGFP U2OS cell line.

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5 mg ¥1980 In stock
10 mg ¥2980 In stock
25 mg ¥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ARN25068 is a highly potent, triple GSK-3β/FYN/DYRK1A inhibitor with IC50 of 4.17 and 2.17 μM for GSK-3β and FYN, reduces the extent of tau phosphorylation in Tau0N4R-TM-tGFP U2OS cell line.

物理化学性质&存储条件

分子量 362.455
分子式 C19H18N6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N2-benzyl-N4-(3-cyclopropyl-1H-pyrazol-5-yl)thieno[3,2-d]pyrimidine-2,4-diamine

参考文献

1. Stefania Demuro, et al. Eur J Med Chem. 2022 Feb 5;229:114054.

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