Receptor Interacting Protein Kinase (RIPK) compound (inhibitors, antagonists, agonists)-ProbeChem.com

Request The Product List ofReceptor Interacting Protein Kinase (RIPK) Receptor Interacting Protein Kinase (RIPK)

Cat. No.	Product Name	Information
PC-25449	Zharp1-163 Ferroptosis/necroptosis inhibitor	Zharp1-163 is a dual inhibitor of ferroptosis and necroptosis, effectively blocks ferroptosis by reducing reactive oxygen species (ROS) levels and inhibits necroptosis by potently and selectively targeting RIPK1 kinase (IC50=406.1 nM).
PC-24972	Ocadusertib RIPK1 inhibitor	Ocadusertib (LY3871801, R552) is a potent and selective, allosteric inhibitor of RIPK1 with IC50 of 12-38 nM.
PC-24570	LK01003 RIPK3 inhibitor	LK01003 is a potent, highly selective inhibitor targeting RIPK3 with IC50 of 2 nM in ADP-Glo assays, shows anti-necroptotic activities in L929 cells with EC50 of 3.7 uM.
PC-22143	UH15-38 RIPK3 inhibitor	UH15-38 is a potent, specific receptor interacting protein kinase 3 (RIPK3) inhibitor with IC50 of 20 nM in NanoBRET assays, potently and selectively blocks IAV-triggered necroptosis in alveolar epithelial cells in vivo.
PC-21478	GSK840 RIPK3 inhibitor	GSK840 is a specific small-molecule inhibitor of RIPK3 with IC50 of 0.9 nM, specifically inhibit RIPK3/MLKL-dependent necroptosis.
PC-21082	Zharp2-1 RIPK2 inhibitor	Zharp2-1 is a novel potent, selective RIPK2 inhibitor with IC50 of 38.5 nM in ADP-Glo kinase assay, effectively blocks RIPK2 kinase function and NOD-mediated NF-κB/MAPK activation.
PC-20063	Oditrasertib RIPK1 inhibitor	Oditrasertib (DNL788, SAR443820) is a potent, selective, orally bioavailable, brain penetrant inhibitor RIPK1 inhibitor with IC50 of 3.16 nM in human PBMCs and 1.6 nM in induced pluripotent stem cell (iPSC)-derived microglia.
PC-20036	Flizasertib RIPK1 inhibitor	Flizasertib (GDC-8264) is a potent, selective receptor-interacting protein 1 (RIP1, RIPK1) inhibitor with Kiapp of 0.71 nM.
PC-49810	RIPK2 inhibitor 3 RIPK2 inhibitor	RIPK2 inhibitor 3 is a potent, selective inhibitor of RIP2 kinase (RIPK2), displays equivalent potency to inhibitor RIPK2 inhibitor 3 in biochemical assays, phosphate ester prodrug.
PC-49455	RI-962 RIPK1 inhibitor	RI-962 (RI 962) is a potent and selective RIPK1 inhibitor with IC50 of 5.9 nM in ADP-Glo assays.
PC-49449	Zharp1-211 RIPK1 inhibitor	Zharp1-211 is a potent, selective, type II inhibitor of RIPK1 kinase with IC50 of 53 nM and binding Kd of 8.7 nM.
PC-49126	GNE684 RIPK1 inhibitor	GNE684 (GNE 684) is a potent, cross-species, specific RIP1 kinase (RIPK1) inhibitor with IC50 of 21, 189 and 691 nM for human, mouse and rat RIP1, respectively.

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