| Cat. No. |
Product Name |
Information |
| PC-49810 |
RIPK2 inhibitor 3
RIPK2 inhibitor
|
RIPK2 inhibitor 3 is a potent, selective inhibitor of RIP2 kinase (RIPK2), displays equivalent potency to inhibitor RIPK2 inhibitor 3 in biochemical assays, phosphate ester prodrug. |
| PC-49455 |
RI-962
RIPK1 inhibitor
|
RI-962 (RI 962) is a potent and selective RIPK1 inhibitor with IC50 of 5.9 nM in ADP-Glo assays. |
| PC-49449 |
Zharp1-211
RIPK1 inhibitor
|
Zharp1-211 is a potent, selective, type II inhibitor of RIPK1 kinase with IC50 of 53 nM and binding Kd of 8.7 nM. |
| PC-49126 |
GNE684
RIPK1 inhibitor
|
GNE684 (GNE 684) is a potent, cross-species, specific RIP1 kinase (RIPK1) inhibitor with IC50 of 21, 189 and 691 nM for human, mouse and rat RIP1, respectively. |
| PC-47116 |
AS3334034
RIPK2 inhibitor
|
AS3334034 is a potent, selective inhibitor of the receptor-interacting protein kinase 2 (RIPK2) with IC50 of 3.02 and 2.10 nM for rat and human RIP2 kinase activity, respectively. |
| PC-38781 |
Dusquetide
p62 modulator
|
Dusquetide (SGX-942, SGX94) is a 5-amino acid peptide, cell membrane penetrant innate defense regulator (IDR) that modulates the innate immune response to both PAMPs and DAMPs, targets the ZZ domain of p62 and modulates the p62-RIP1 complex. |
| PC-38621 |
ZJU-37
RIPK1 inhibitor
|
ZJU-37 is a novel small molecule, BBB penetrant RIPK1 kinase inhibitor (IC50=366.4 nM) with higher potency than Nec-1s, prevents TNFα-induced necroptosis of Jurkat FADD−/− cells with IC50 of 185.2 nM. |
| PC-38490 |
GSK-843
RIPK3 inhibitor
|
GSK-843 (GSK'843) is a specific small molecule receptor-interacting protein kinase 3 (RIPK3) inhibitor, binds to RIP3 kinase domain with high affinity (IC50=8.6 nM). |
| PC-73179 |
GSK2983559-AM
RIPK2 inhibitor
|
GSK2983559-AM is the acitve form of GSK2983559, a potent, selective RIPK2 with IC50 of 5 nM. |
| PC-73178 |
GSK2983559
RIPK2 inhibitor
|
GSK2983559 is a potent, selective and orally active receptor interacting protein 2 kinase (RIPK2) inhibitor with IC50 of 7 nM. |
| PC-73017 |
PK68
RIPK1 inhibitor
|
PK68 (RIPK1 inhibitor PK68) is a potent necroptosis inhibitor seletively targeting RIPK1 kinase activity, potently inhibits TNF-induced necroptosis (EC50, 23 and 13 nM in human and mouse cells, respectively). |
| PC-73007 |
Necrostatin-34
RIPK1 inhibitor
|
Necrostatin-34 (Nec-34) is a novel small molecule inhibitor of RIPK1 kinase, inhibits TNFα-induced necroptosis in FADD-deficient Jurkat cells with IC50 of 0.67 uM. |
