Dusquetide (SGX942) | p62 modulator | Probechem Biochemicals

Chemical Structure : Dusquetide

CAS No.: 931395-42-5

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Dusquetide (SGX942, SGX94)

货号: PC-38781Not For Human Use, Lab Use Only.

Dusquetide (SGX-942, SGX94) is a 5-amino acid peptide, cell membrane penetrant innate defense regulator (IDR) that modulates the innate immune response to both PAMPs and DAMPs, targets the ZZ domain of p62 and modulates the p62-RIP1 complex.

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5 mg	￥1880	In stock
10 mg	￥2780	In stock
25 mg	￥4580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Dusquetide (SGX-942, SGX94) is a 5-amino acid peptide, cell membrane penetrant innate defense regulator (IDR), targets the ZZ domain of p62 and modulates the p62-RIP1 complex.
Dusquetide penetrates the cell membrane and associates with p62 in vivo.
Dusquetide binding modulates the p62-RIP1 complex, increases p38 phosphorylation, and enhances CEBP/B expression without activating autophagy.
Dusquetide reduces the duration of mucositis in preclinical animal models, and in Phase 2a clinical studys.

物理化学性质&存储条件

分子量	553.709
分子式	C25H47N9O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(L-arginyl-L-isoleucyl-L-valyl)-N-((S)-1-amino-1-oxopropan-2-yl)pyrrolidine-2-carboxamide

参考文献

1. Yi Zhang, et al. Structure. May 30, 2022

2. Mahesh Kudrimoti, et al. J Biotechnol. 2016 Dec 10;239:115-125.

Dusquetide (SGX942, SGX94)

生物&药学活性

物理化学性质&存储条件

参考文献

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Dusquetide (SGX942, SGX94)

生物&药学活性

物理化学性质&存储条件

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