| Cat. No. |
Product Name |
Information |
| PC-28052 |
QX03-46
CTGF inhibitor
|
QX03-46 is a first-in-class small-molecule inhibitor targeting connective tissue growth factor (CTGF), significantly disrupts the CTGF/TGF-β1 signaling axis and suppresses cancer-associated fibroblast (CAF) functions, resulting in decreased extracellular matrix deposition and oncogenic cytokine secretion in PDAC. |
| PC-26693 |
M4K2163 dihydrochloride
ALK2 inhibitor
|
M4K2163 dihydrochloride is a potent, selective, blood-brain barrier (BBB) permeable activin receptor-like kinase-2 (ALK2) inhibitor with IC50 of 19 nM. |
| PC-25943 |
KTI-2338
ALK2 inhibitor
|
KTI-2338 is a potent, selective ALK2 (Activin A receptor type 1, ACVR1) inhibitor with IC50 of 3.6 nM, >75-fold selective over ALK5 and ALK1. |
| PC-24919 |
LY-364947
TGFβR1 inhibitor
|
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of type I TGF-beta receptor kinase (TGFβR-I, ALK5) with IC50 of 59 nM, 7-fold selectivity over TGFβR-II. |
| PC-24853 |
RK783
ACVR1 inhibitor
|
RK783 is a potent, selective inhibitor inhibitor of BMP type 1 receptor kinase (ACVR1), inhibits CVR1-Q207D, ACVR1-R206H, wild-type ACVR1, and other BMP type 1 receptor kinases with IC50 of 10-120 nM. |
| PC-24588 |
GFH018
TGF-βRI inhibitor
|
GFH018 is a small molecule inhibitor of transforming growth factor-β receptor I (TGF-βRI, ALK5) inhibitor with IC50 of 40 nM, >60-fold selective over p38α MAPK. |
| PC-24274 |
HM-279
ALK5 inhibitor
|
HM-279 is a potent, selective, orally bioavailable inhibitor of ALK5 (TGFβR1) with IC50 of 4.7 nM, strongly inhibits the phosphorylation of Smad3 in A549 cells (IC50=21.6 nM). |
| PC-24165 |
Ontunisertib
ALK5 inhibitor
|
Ontunisertib (AGMB-129, AGMB129) is a potent, selective, oral, gastrointestinal-restricted TGF-beta type I receptor (TGFβRI)/ALK5 kinase inhibitor. |
| PC-23803 |
C-5635020
TGFβ RII inhibitor
|
C-5635020 is a potent and selective inhibitor of TGFβ type II receptor (TGFβ RII), binds to TGFβ RII with a docking score of -13.9 kcal/mol. |
| PC-22015 |
M4K2009
ALK2 inhibitor
|
M4K2209 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 9 nM, >180-fold selective over ALK5 (IC50=2427 nM). |
| PC-22014 |
M4K2304
ALK2 inhibitor
|
M4K2304 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 3 nM, >800-fold selective over ALK5. |
| PC-21414 |
Itacnosertib
ALK2 inhibitor
|
Itacnosertib (TP-0184) is a novel potent, selective inhibitor of type I bone morphogenetic protein (BMP) receptor ACVR1 (activin A receptor-type 1, ALK2) and FLT3 with IC50 of 8.0 nM (ALK2). |
