M4K2009

Chemical Structure : M4K2009

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货号: PC-22015Not For Human Use, Lab Use Only.

M4K2209 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 9 nM, >180-fold selective over ALK5 (IC50=2427 nM).

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生物&药学活性

M4K2209 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 9 nM, >180-fold selective over ALK5 (IC50=2427 nM).
M4K2209 shows cell IC50 of 26 nM in NanoBRET target engagement assay.
M4K2209 is equipotent against both wild-type (WT) and mutant ALK2 (G328V, R206H, and R258G) in the biochemical kinase assay.
M4K2009 is also moderately active against the hERG potassium channel (IC50= 8 uM).

物理化学性质&存储条件

分子量	419.53
分子式	C25H29N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine

参考文献

1. Ensan D, et al. J Med Chem. 2020 May 14;63(9):4978-4996.

M4K2009

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物理化学性质&存储条件

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M4K2009

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