| Cat. No. |
Product Name |
Information |
| PC-28772 |
AgrC inhibitor CP-20t
S. aureus AgrC inhibitor
|
CP-20t is a potent, small molecule inhibitor of Staphylococcus aureus agr quorum sensing (QS) system with IC50 of 9.8 nM (agr group-I), acts on AgrC and blocks hemolysis of rabbit red blood cells by group-I S. aureus with IC50 of 18 nM. |
| PC-28760 |
SLU-1642
P. aeruginosa MexF inhibitor
|
SLU-1642 is a specific small-molecule inhibitor that selectively targets P. aeruginosa MexF and its closest homologs, but not major efflux pumps such as MexB, specifically potentiates the activity of antibiotic substrates of MexF in P. aeruginosa hyperporinated strains overexpressing MexF. |
| PC-28699 |
APC24-7
Meropenem potentiator
|
APC24-7 is a covalent combination of boronic acid and chelator moieties, restores β-lactam efficiency against metallo-β-lactamase-producers, sensitizesclinical isolates of SBL- and MBL-producing Klebsiella pneumoniae and Escherichia coli to meropenem. |
| PC-28698 |
MprB-IN-1
Mtb MprB inhibitor
|
MprB-IN-1 (Compound 7a) is a small molecule inhibitor of Mycobacterium tuberculosis (Mtb) histidine kinase MprB, reduces ESX-1-dependent pathogenicity, prevents dissemination of Mtb from the lung to the spleen in mouse model of acute TB infection. |
| PC-28619 |
ETX1975-3
Mtb Cyt-bd inhibitor
|
ETX1975-3 is a potent Mycobacterium tuberculosis (Mtb) cytochrome bd oxidase (Cyt-bd) inhibitor with ATP IC50 of 1.7 uM and MIC of 5.0 uM for M. abscessus ΔqcrCAB strain. |
| PC-28618 |
HM2-16F
Mtb Cyt-bd inhibitor
|
HM2-16F is an anti-tubercular inhibitor with bactericidal properties that inhibiting cytochrome bd oxidase (Cyt-bd), inhibits the growth of bedaquiline-resistant mutants, weakly inhibits F1Fo-ATP synthase, depletes ATP, and affects the entry of acetyl-CoA into the Krebs cycle, synergizes with the cytochrome bcc-aa3 oxidase inhibitor Q203 (Telacebec). |
| PC-28616 |
YH-685
Mtb Cyt-bd inhibitor
|
YH-685 is a specific small molecule inhibitor of Mycobacterium tuberculosis (Mtb) cytochrome bd terminal oxidase (Cyt-bd), inhibits Cyt-bcc-deficient M. smegmatis with MIC of 0.8 uM, enhances TB47-mediated inhibition of planktonic and intracellular Mtb. |
| PC-28500 |
LBM-415
Peptide deformylase inhibitor
|
LBM-415 (LBM415, NVP-PDF713, VIC-104959) is a potent bacterial peptide deformylase (PDF) inhibitor, exhibits inhibitory activity against various antimicrobial-resistant gram-positive cocci with MIC90 range of 0.12-8 ug/mL. |
| PC-28359 |
DksA inhibitor Compound 916
DksA inhibitor
|
DksA inhibitor Compound 916 is a small molecule inhibitor of Gram-negative bacteria DksA protein, inhibits DksA-mediated repression of rpsM in vitro transcription with IC50 of 928 nM, has MIC50 of 32 ug/mL against nontyphoidal S. enterica serovar Typhimurium strain 14028s and E. coli strain W3110. |
| PC-28358 |
VKT-17-P4-23
DksA inhibitor
|
VKT-17-P4-23 is a small molecule inhibitor of Gram-negative bacteria DksA protein, inhibits DksA-mediated repression of rpsM in vitro transcription with IC50 of 72 nM, has MIC50 of 16 ug/mL against S. Typhimurium. |
| PC-28303 |
VMP-7
Mtb GlgE inhibitor
|
VMP-7 is a small molecule inhibitor of Mycobacterium tuberculosis (M.tb) maltosyltransferase (GlgE), a key enzyme in the α-glucan biosynthesis pathway of M.tb, exhibits significant inhibitory activity against M.tb with MIC of 15.5 ug/mL. |
| PC-28183 |
DDD00079282
Mtb GuaB inhibitor
|
DDD00079282 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB, MtbIMPDH) with Ki of 0.22 uM, does not inhibit human IMPDH, shows antitubercular activity against Mtb H37Rv with MIC of 2 uM. |