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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial

Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-23141

LolCDE-IN-1

LolCDE inhibitor

LolCDE-IN-1 is a small molecule antibacterial agent targeting the ABC transporter complex LolCDE, inhibits bacterial growth by targeting LolCDE to block lipoprotein transport to the outer membrane.
PC-23136

MAC-0452936

E. coli Lgt inhibitor

MAC-0452936 is a specific small molecule inhibitor of prolipoprotein diacylglyceryl transferase, Lgt, in Escherichia coli, with IC50 of 1.45 uM (DDM-Lgt).
PC-23128

PTB2

BamA inhibitor

PTB2 is a 14-amino acid macrocyclic peptide BamA inhibitor with MIC of 4 µg/mL (2 µM) against wild-type E. coli, binds to the open lateral gate BamA.
PC-23127

PTB2-1

BamA inhibitor

PTB2-1 is an E. coli-specific BamA inhibitor with MIC of 4 ug/mL, inactive against other bacterial species, decreases OMP levels, decreased activity of the OmpT enzyme, increases outer membrane permeability.
PC-23126

PTB1

BamA inhibitor

Peptide Targeting BamA-1 (PTB1) is a 12-amino acid macrocycle, multi-species BamA inhibitor, binds to purified BamA with SPR Kd of 50 pM, has MIC of 42 ug/mL (25 uM) against wild-type E. coli strain.
PC-22986

G247

MsbA inhibitor

G247 is a specific MsbA inhibitor, reduces MsbA NBD dimerization efficiency and ATPase activity.
PC-22958

Virstatin

ToxT inhibitor

Virstatin is a small-molecule inhibitor of transcription factor ToxT, inhibits the pili system synthesis and prevents A. baumannii biofilm formation, reduces virulence in vitro.
PC-22943

Ridinilazole

C. difficile inhibitor

Ridinilazole (SMT19969) is a narrow-spectrum, non-absorbable antimicrobial against Clostridium difficile with MIC of 0.125 to 0.5 ug/ml, MIC90 of 0.25 ug/mL, including ribotype 027 strains.
PC-22942

Ramoplanin

Antibiotic

Ramoplanin (A-16686) is a glycolipodepsipeptide antibiotic with MIC50 of 1.45 ug/mL against methicillin-resistant S. epidermidis (MRSE), shows activity against staphylococci, enterococci and C. difficile.
PC-22941

OPS-2071

C. difficile inhibitor

OPS-2071 is a novel quinolone antibacterial agent with potent antibacterial activity against 54 clinically isolated C. difficile strains with MIC50 of 0.125 ug/mL, reduces the risk of adverse events typical of fluoroquinolone class antibiotics.
PC-22849

PBZ1587

GroES/GroEL inhibitor

PBZ1587 is a small-molecule inhibitor of the GroES/GroEL chaperone system with IC50 of 0.44 uM in MDH refolding assay, binds at the GroEL ring–ring interface (RRI).
PC-22848

PBZ1038

GroES/GroEL inhibitor

PBZ1038 is a small-molecule inhibitor of the GroES/GroEL chaperone system with IC50 of 1.2 uM against E. faecium GroES/GroEL refolding of malate dehydrogenase (MDH), binds at the GroEL ring–ring interface (RRI).

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