Cat. No. |
Product Name |
Information |
PC-23141 |
LolCDE-IN-1
LolCDE inhibitor
|
LolCDE-IN-1 is a small molecule antibacterial agent targeting the ABC transporter complex LolCDE, inhibits bacterial growth by targeting LolCDE to block lipoprotein transport to the outer membrane. |
PC-23136 |
MAC-0452936
E. coli Lgt inhibitor
|
MAC-0452936 is a specific small molecule inhibitor of prolipoprotein diacylglyceryl transferase, Lgt, in Escherichia coli, with IC50 of 1.45 uM (DDM-Lgt). |
PC-23128 |
PTB2
BamA inhibitor
|
PTB2 is a 14-amino acid macrocyclic peptide BamA inhibitor with MIC of 4 µg/mL (2 µM) against wild-type E. coli, binds to the open lateral gate BamA. |
PC-23127 |
PTB2-1
BamA inhibitor
|
PTB2-1 is an E. coli-specific BamA inhibitor with MIC of 4 ug/mL, inactive against other bacterial species, decreases OMP levels, decreased activity of the OmpT enzyme, increases outer membrane permeability. |
PC-23126 |
PTB1
BamA inhibitor
|
Peptide Targeting BamA-1 (PTB1) is a 12-amino acid macrocycle, multi-species BamA inhibitor, binds to purified BamA with SPR Kd of 50 pM, has MIC of 42 ug/mL (25 uM) against wild-type E. coli strain. |
PC-22986 |
G247
MsbA inhibitor
|
G247 is a specific MsbA inhibitor, reduces MsbA NBD dimerization efficiency and ATPase activity. |
PC-22958 |
Virstatin
ToxT inhibitor
|
Virstatin is a small-molecule inhibitor of transcription factor ToxT, inhibits the pili system synthesis and prevents A. baumannii biofilm formation, reduces virulence in vitro. |
PC-22943 |
Ridinilazole
C. difficile inhibitor
|
Ridinilazole (SMT19969) is a narrow-spectrum, non-absorbable antimicrobial against Clostridium difficile with MIC of 0.125 to 0.5 ug/ml, MIC90 of 0.25 ug/mL, including ribotype 027 strains. |
PC-22942 |
Ramoplanin
Antibiotic
|
Ramoplanin (A-16686) is a glycolipodepsipeptide antibiotic with MIC50 of 1.45 ug/mL against methicillin-resistant S. epidermidis (MRSE), shows activity against staphylococci, enterococci and C. difficile. |
PC-22941 |
OPS-2071
C. difficile inhibitor
|
OPS-2071 is a novel quinolone antibacterial agent with potent antibacterial activity against 54 clinically isolated C. difficile strains with MIC50 of 0.125 ug/mL, reduces the risk of adverse events typical of fluoroquinolone class antibiotics. |
PC-22849 |
PBZ1587
GroES/GroEL inhibitor
|
PBZ1587 is a small-molecule inhibitor of the GroES/GroEL chaperone system with IC50 of 0.44 uM in MDH refolding assay, binds at the GroEL ring–ring interface (RRI). |
PC-22848 |
PBZ1038
GroES/GroEL inhibitor
|
PBZ1038 is a small-molecule inhibitor of the GroES/GroEL chaperone system with IC50 of 1.2 uM against E. faecium GroES/GroEL refolding of malate dehydrogenase (MDH), binds at the GroEL ring–ring interface (RRI). |