| Cat. No. |
Product Name |
Information |
| PC-21395 |
NBI-961
NEK2 inhibitor
|
NBI-961 is a highly potent, selective inhibitor of NIMA related Kinase 2 (NEK2) and FLT3 with IC50 of 32 nM and 37 nM, respectively. |
| PC-20311 |
Nek2 inhibitor 66
Nek2 inhibitor
|
Nek2 inhibitor 66 (NCL-00017509) is a potent, selective and irreversible inhibitor of Nek2 with IC50 of 62 nM, exhibits growth inhibitory activity in the SKBR3 cell line with GI50 of 2.2 uM. |
| PC-20310 |
T-1101 tosylate
Hec1-Nek2 inhibitor
|
T-1101 tosylate (TAI-95 tosylate) is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=14.29-73.65 nM, breast cancer cell lines). |
| PC-20309 |
JH295
Nek2 inhibitor
|
JH295 (JH-295) is a potent, selective and irreversible Nek2 kinase inhibitor with IC50 of 770 nM, inhibits Nek2 via alkylation of residue Cys22, does not inhibit Cdk1/CycB (IC50>20 uM). |
| PC-20308 |
CCT241950
Nek2 inhibitor
|
CCT241950 (CCT 241950) is a small molecule NEK2 inhibitor, induces Tyr70Nek2 to jut into the ADP-binding pocket. |
| PC-61484 |
HCI-2389
Nek2 inhibitor
|
HCI-2389 is a potent, specific, irreversible NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 16.65 nM. |
| PC-61483 |
Nek2 inhibitor (R)-21
Nek2 inhibitor
|
A potent and selective NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 22 nM, >200-fold selectivity over Plk1, Mps1, Aurora A and CDK2. |
| PC-61482 |
TAI-95
Hec1-Nek2 inhibitor
|
TAI-95 (T-1101, TAI 95) is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=14.29-73.65 nM, breast cancer cell lines). |
| PC-61481 |
TAI-1
Hec1-Nek2 inhibitor
|
TAI-1 is a potent, small molecule Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=13.48 nM K562 cells). |
| PC-61480 |
INH154
Hec1/Nek2 inhibitor
|
INH154 is a novel small molecules disrupting Hec1/Nek2 interaction, inhibits HeLa and MDA-MB-468 cancer cells growth with IC50 of 0.20 and 0.12 uM, respectively. |
| PC-61479 |
Nek2 inhibitor 72
Nek2 inhibitor
|
Nek2 inhibitor 72 is a potent, ATP-competitive and relative selective Nek2 inhibitor with IC50 of 0.27 uM. |
| PC-61478 |
Nek2 inhibitor 3a
Nek2 inhibitor
|
Nek2 inhibitor 3a is a potent, relatively selective Nek2 inhibitor with IC50 of 82.74 nM in cell-free assays. |
