JH295 | Nek2 inhibitor | Probechem Biochemicals

Chemical Structure : JH295

CAS No.: 1311143-71-1

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JH295 (JH-295)

货号: PC-20309Not For Human Use, Lab Use Only.

JH295 (JH-295) is a potent, selective and irreversible Nek2 kinase inhibitor with IC50 of 770 nM, inhibits Nek2 via alkylation of residue Cys22, does not inhibit Cdk1/CycB (IC50>20 uM).

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10 mg	￥5480	In stock
25 mg	￥8980	In stock
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生物&药学活性

JH295 (JH-295) is a potent, selective and irreversible Nek2 kinase inhibitor with IC50 of 770 nM, inhibits Nek2 via alkylation of residue Cys22, does not inhibit Cdk1/CycB (IC50>20 uM).
JH295 selectively and irreversibly inhibits cellular Nek2 without affecting the mitotic kinases, Cdk1, Aurora B, or Plk1, does not perturb bipolar spindle assembly or the spindle assembly checkpoint.
JH295 inhibits cellular Nek2 in a Cys22-dependent manner, inhibits WT Nek2 in cells with IC50 of 1.6 uM in IP kinase assays, shows little effect on the C22V mutant.
JH295 does not perturb bipolar spindle assembly or chromosome congression.

物理化学性质&存储条件

分子量	320.35
分子式	C18H16N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(3Z)-3-[(2-Ethyl-4-methyl-1H-imidazol-5-yl)methylene]-2,3-dihydro-2-oxo-1H-indol-5-yl]-2-propynamide

参考文献

1. Henise JC, et al. J Med Chem. 2011 Jun 23;54(12):4133-46.

JH295 (JH-295)

生物&药学活性

物理化学性质&存储条件

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JH295 (JH-295)

生物&药学活性

物理化学性质&存储条件

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