| Cat. No. |
Product Name |
Information |
| PC-24472 |
KTX207
PDE4 PROTAC
|
KTX207 is a potent, selective BI 1015550-based PDE4 PROTAC degrader, degrades PDE4D and PDE4B shortforms in A549 cells with IC50 of 10 pM and 400 pM, respectively. |
| PC-24182 |
KT-253
MDM2 degrader
|
Seldegamadlin (KT-253, KT253) is a potent, selective heterobifunctional MDM2 degrader (DC50=0.4 nM) and p53 stabilizer. |
| PC-23963 |
DEG-77
IKZF2/CK1α degarder
|
DEG-77 is a more soluble analog of DEG-35, dual degrader of IKZF2 and casein kinase 1α (CK1α) with DC50 of 15.3 nM and 10 nM respectively. |
| PC-23961 |
DEG-35
IKZF2/CK1α degarder
|
DEG-35 is a potent, cereblon-dependent, dual degrader of IKZF2 ((DC50=4.4 nM, DCmax=92%)) and casein kinase 1α (CK1α, DC50=1.4 nM, DCmax=84%), shows leukemic cell killing activity. |
| PC-23910 |
QZ2135
RET PROTAC
|
QZ2135 is a potent, selective RET PROTAC degrader, effectively degrades RET kinase (DC50=4.7 nM) and its resistant mutants, such as V804M (DC50=17.2 nM) and G810C/R. |
| PC-23898 |
FTO PROTAC QP73
FTO degrader
|
FTO PROTAC QP73 is a first-in-class PROTAC degrader for the RNA demethylase FTO, efficiently induces FTO protein degradation in a dose-, time-, cereblon (CRBN)-, and proteasome-dependent manner in AML cells (DC50=34.9 nM, NB4 cells). |
| PC-23772 |
HLB-0532259
Aurora-A PROTAC
|
HLB-0532259 is a potent, selective Aurora-A PROTAC degrader with DC50 of 20.2 nM in non-MYCN amplified MCF-7 cells. |
| PC-23403 |
MS105
PTK6 PROTAC
|
MS105 is a potent, selective protein tyrosine kinase 6 (PTK6) PROTAC degrader, specifically and potently degrades PTK6 in a proteasome and VHL-dependent manner with DC50 of 21 nM and Dmax of 84% in MDA-MB-231/LM2-4 cells. |
| PC-23149 |
YJ1206
CDK12/13 PROTAC
|
YJ1206 is a selective, orally bioavailable CDK12/13 PROTAC degrader, shows potent degradation effects and inhibits VCaP cell viability (IC50=12.5 nM). |
| PC-22955 |
MS8588
cGAS DUBTAC
|
MS8588 is a first-in-class DUBTAC of cGAS, a key component of the cGAS-STING pathway, stabilizes cGAS and increases the cGAS downstream effector protein STING. |
| PC-22954 |
MS7829
cGAS DUBTAC
|
MS7829 is a first-in-class DUBTAC of cGAS, a key component of the cGAS-STING pathway, stabilizes cGAS and increases the cGAS downstream effector protein STING. |
| PC-22897 |
HPK1 PROTAC C3
HPK1 PROTAC
|
HPK1 PROTAC C3 is a potent, selective and orally active HPK1 PROTAC degrader with DC50 of 21.26 nM, Dmax of 80.50% in Jurkat cells. |
