| Cat. No. |
Product Name |
Information |
| PC-25674 |
AMPTX1
BRD9 degrader
|
AMPTX-1 is a potent, selective and reversibly covalent BRD9 degrader with DC50 of 0.5 nM and Dmax =93% (MV4-11 cell, 6h). |
| PC-25670 |
Golcadomide
IKZF1/3 degrader
|
Golcadomide (CC-99282) is a potent, oral cereblon-modulating CELMoD agent that acts as cereblon-based molecular glue degrader of both IKZF1 and IKZF3. |
| PC-25655 |
EPIC-0726
PTRF PROTAC
|
EPIC-0726 is a selective PROTAC degrader of polymerase I and transcript release factor (PTRF/Cavin1) with DC50 of 5.12 uM in U87-MG cells, Dmax=90.07%. |
| PC-25623 |
MA203
CHK1 PROTAC
|
MA203 is a potent, selective Checkpoint kinase-1 (CHK1) PROTAC degarder with DC50 of 5 uM in MIA PaCa-2 (24 h). |
| PC-25610 |
ZJK-807
KRAS G12D PROTAC
|
ZJK-807 is a selective, cereblon (CRBN)-based proteolysis-targeting chimera (PROTAC) degrader of KRASG12D with DC50 of 79.5 nM in AsPC-1 cells (Dmax=92%), with minimal impact on wild-type KRAS or other mutants (G12C/S/V, G13D) KRAS proteins. |
| PC-25493 |
FTO degrader FP54
FTO PROTAC
|
FTO degrader FP54 is a selective PROTAC degrader of fat mass and obesity-associated protein (FTO) with DCof 0.68 μM in NB4 cells and 0.71 μM in MOLM-13 cells, Dmax>95%. |
| PC-25407 |
ASP3082
KRAS G12D PROTAC
|
Setidegrasib (ASP3082) is a potent, selective KRAS G12D PROTAC degrader with DC50 of 38 nM, effectively induces KRAS(G12D) protein degradation with remarkable selectivity. |
| PC-25335 |
ABS-752 hydrochloride
GSPT1/NEK7 degrader
|
ABS-752 hydrochloride is a prodrug of ABT-002 that could be activated by the monoamine oxidase VAP-1, ABS-752 is a molecular glue degrader of GSPT1 and NEK7 with DC50 of 1 nM and 9 nM in Hep3B cells (24 h, Dmax>95%). |
| PC-25334 |
ABS-752
GSPT1/NEK7 degrader
|
ABS-752 is a prodrug of ABT-002 that could be activated by the monoamine oxidase VAP-1, ABS-752 is a molecular glue degrader of GSPT1 and NEK7 with DC50 of 1 nM and 9 nM in Hep3B cells (24 h, Dmax>95%). |
| PC-25326 |
JWJ-01-368
ZBTB11 degrader
|
JWJ-01-368 is a negative control compound of JWJ-01-306, which lacks the aromatic CF3 substituent crucial for achieving potent ZBTB11 degradation, efficiently binds CRBN but failed to promote both ZBTB11 ternary complex formation and ZBTB11 degradation. |
| PC-25325 |
JWJ-01-306
ZBTB11 degrader
|
JWJ-01-306 is a potent and selective molecular glue degrader of transcription factor ZBTB11 with DC50 of 620 nM, Dmax, 10 µM of 80%, in MIA PaCa-2 cells. |
| PC-25288 |
UNC6587
TBK1 PROTAC
|
UNC6587 is a selective cereblon-based TBK1 proteolysis targeting chimera (PROTAC) degrader, efficiently eliminates TBK1 protein levels in ccRCC cells, while not affecting its close family member IKKε. |
