| Cat. No. |
Product Name |
Information |
| PC-28645 |
PVD-06
PTPN2 degrader
|
PVD-06 is a potent, subtype-selective PTPN2 (TCPTP) degrader with DC50 of 216 nM in Jurkat cells, >60-fold selectivity over PTP1B. |
| PC-28644 |
PD-305
PTPN2 degrader
|
PD-305 is a potent, selective PTPN2 (TCPTP) PROTAC degrader with DC50 of 0.25 nM in Jurkat cell line, possessing 20-fold PTPN2/PTPN1 subtype selectivity (PTPN1, DC50=5.11 nM). |
| PC-28642 |
HDAC4 PROTAC TP1
HDAC4 degrader
|
HDAC4 PROTAC TP1 is a potent, selective Tasquinimod-based PROTAC degrader of HDAC4, exhibits radiosensitizing effectsby enhancing ferroptosis in lung cancer. |
| PC-28641 |
dAR-6-1
AR degrader
|
dAR-6-1 is a potent androgen receptor (AR) PROTAC degrader with DC50 of 0.23 nM in hDPC (Dmax=90%) and 0.90 nM in LNCaP (Dmax=91%), induces hair regeneration in androgenetic alopecia (AGA) mouse model. |
| PC-28640 |
NCP07
ERα degrader
|
NCP07 is a potent, ERα coactivator-binding site (CBS) targeting PROTAC degrader of ERα, degrades ERα and its mutants in breast cancer cells, significantly degrades ERα (DC50<10 uM) in MCF-7, T47D and ESR1 mutant breast cancer cells (MCF-7EGFR, MCF-7D538G and MCF-7Y537S). |
| PC-28638 |
DDX18 degrader M12
DDX18 degrader, DCAF11-binding warhead
|
DDX18 degrader M12 is a molecular glue degrder of DDX18 that reprogrammes the E3 ligase DCAF11 to degrade DDX18, functions as a prodrug that is activated through glutathione S-transferase-mediated glutathionylation. |
| PC-28568 |
MR-9036
ULK1 degrader
|
MR-9036 is a potent, selective cereblon-recruiting ULK1 degrader with DC50 of 67 nM in MOLT-4 cells. |
| PC-28565 |
HQY1480
EGFR PROTAC
|
HQY1480 is a potent, selective and next-generation EGFR-mutant PROTAC derived from BI-4020 with DC50 of 0.9 nM and 0.7 nM in Ba/F3LR/TM and Ba/F3LR/TM/CS cells, overcomes osimertinib resistance, targets EGFRL858R/T790M/C797S (LR/TM/CS) triple mutant, but not wild-type EGFR protein. |
| PC-28561 |
WW-210
STAT6 PROTAC
|
WW-210 is a potent, selective, and orally efficacious STAT6 PROTAC degrader with DC50 of 0.025 nM in Jurkat cells and 0.018 nM in hPBMC. |
| PC-28558 |
PTP1B and TCPTP degrader X1
PTP1B/TCPTP PROTAC
|
PTP1B and TCPTP degrader X1 is a potent, selective CRBN-based PROTAC dual degrader of PTP1B/TCPTP with DC50 of 8.9 nM and 6.2 nM respectively in HEK293 cells. |
| PC-28478 |
IAP-08
SMYD3 PROTAC
|
IAP-08 is a potent, selective SMYD3 proteolysis targeting chimera (PROTAC) degrader with DC50 of 177 nM and Dmax of 90% in HiBiT-tagged SMYD3 expressing HN13 cells, effectively induces the formation of ternary complexes with SMYD3 and the XIAP E3 ligase. |
| PC-28444 |
AMC-3-221
CDK9 PROTAC
|
AMC-3-221 is a potent, CDK9-selective PROTAC degrader with DC50 of <10 nM and antileukemic inhibitory potency (IC50<50 nM), shows high selectivity for CDK9 over other family members. |
