| Cat. No. |
Product Name |
Information |
| PC-22314 |
LC-MI-3
IRAK4 degrader
|
LC-MI-3 is a potent, selective and orally bioavailable PROTAC degrader of interleukin-1 receptor-associated kinase 4 (IRAK4) with DC50 of 47.3 nM in RAW264.7 cells, Dmax of 91%. |
| PC-22303 |
JYQ-194
PARK7 degrader
|
JYQ-194 (JYQ194) is a first-in-class, selective PARK7 PROTAC degrader, induces degradation of PARK7 starting at 0.1 uM and reaching a Dmax of 80% at a concentration of 5 uM in A549 cells. |
| PC-22253 |
AKR1C3 PROTAC 5
AKR1C3 degrader
|
AKR1C3 PROTAC 5 is a first-in-class Aldo-Keto reductase 1C3 (AKR1C3) PROTAC degrader with DC50 of 52 nM in 22Rv1 cells, AKR1C1/C2 DC50 of 49 nM, ARv7 DC50 of 70 nM. |
| PC-22219 |
EBET-1593
BET degrader
|
EBET-593 is a bromodomain and extra-terminal (BET) protein degrader, effectively kills PDAC cells, and modulates cancer-associated fibroblasts (CAFs) in PDAC. |
| PC-22215 |
EBET-1055
BET degrader
|
EBET-1055 is a bromodomain and extra-terminal (BET) protein degrader, effectively kills PDAC cells, and modulates cancer-associated fibroblasts (CAFs) in PDAC. |
| PC-22214 |
BR-cpd7
FGFR1/2 degrader
|
BR-cpd7 is a potent, selective FGFR1/2-targeting proteolysis targeting chimeric (PROTAC) degrader with DC50 of 10 nM, while sparing FGFR3. |
| PC-22126 |
LD4172
RIPK1 degrader
|
LD4172 is a first-in-class RIPK1 PROTAC degrader with DC50 values of 4-400 nM in a panel of human and mouse cancer cell lines. |
| PC-22099 |
MS170
AKT PROTAC degrader
|
MS170 (AKT PROTAC degrader) is a potent, selective, cereblon (CRBN)-recruiting AKT PROTAC degrader with DC50 of 32 nM (cellular T-AKT in BT474 cells). |
| PC-22098 |
MS98
AKT PROTAC degrader
|
MS98 (AKT PROTAC degrader) is a potent, selective von Hippel-Lindau (VHL)-recruiting AKT PROTAC degrader with DC50 of 78 nM. |
| PC-22097 |
WH244
BCL-xL/BCL-2 PROTAC
|
WH244 is a potent second-generation dual PROTAC degrader of BCL-2 and BCL-xL with DC50 of 0.6 nM (BCL-xL) and 7.4 nM (BCL-2) in Jurkat cells. |
| PC-22066 |
ZX703
GPX4 degrader
|
ZX703 is a small molecule, ML210-based glutathione peroxidase 4 (GPX4) PROTAC degrader, effectively induces GPX4 degradation with DC50 of 135 nM in HT1080 cell line, Dmax of 86%. |
| PC-22054 |
CBPD-409
CBP/p300 degrader
|
CBPD-409 (CBPD409) is a highly potent, selective, and orally bioavailable CBP/p300 degrader with DC50 0.2-0.4 nM in VCaP, LNCaP, and 22Rv1 AR+ prostate cancer cell lines. |
