| Cat. No. |
Product Name |
Information |
| PC-22066 |
ZX703
GPX4 degrader
|
ZX703 is a small molecule, ML210-based glutathione peroxidase 4 (GPX4) PROTAC degrader, effectively induces GPX4 degradation with DC50 of 135 nM in HT1080 cell line, Dmax of 86%. |
| PC-22054 |
CBPD-409
CBP/p300 degrader
|
CBPD-409 (CBPD409) is a highly potent, selective, and orally bioavailable CBP/p300 degrader with DC50 0.2-0.4 nM in VCaP, LNCaP, and 22Rv1 AR+ prostate cancer cell lines. |
| PC-21920 |
CDK9 PROTAC 45
CDK9 PROTAC
|
CDK9 PROTAC 45 is a highly potent, efficacious CDK9 PROTAC degrader, induces cell apoptosis in vitro and inhibits tumor growth in the MDA-MB-231 TNBC model. |
| PC-21882 |
BTX-6654
SOS1 PROTAC degrader
|
BTX-6654 is a potent, selective SOS1 cereblon-based bifunctional PROTAC degrader, reduces downstream signaling markers, pERK and pS6, and displayed antiproliferative activity in cells harboring various KRAS mutations. |
| PC-21847 |
IBG4
BRD4 degrader
|
IBG4 is a selective, DCAF11-based intramolecular glue/degrader of BRD4, functions via CRL4-DCAF11, shows high specificity for BRD4 and does not efficiently degrade BRD2. |
| PC-21846 |
IBG1
BRD4 degrader
|
IBG1 is a PROTAC-like, specific degrader of BET bromodomain BRD2 and BRD4 with DC50 of 0.15 nM (BRD4), which comprises the BET family bromodomain inhibitor JQ1 tethered to E7820. |
| PC-21776 |
dEALK1
ALK PROTAC
|
dEALK1 is a small-molecule degrader of EML4-ALK fusion proteins with binding constant (Kd) value of 44 nM for kinase domain of recombinant ALK, overcomes resistance to ALK inhibitor ceritinib. |
| PC-21717 |
Chk1 PROTAC-2
Chk1 PROTAC
|
Chk1 PROTAC-2 is a potent Chk1 degrader with DC50 of 1.33 µM in A375 cells. |
| PC-21708 |
PROTAC dCE-1
CBP/EP300 degrader
|
PROTAC dCE-1 is a potent, selective CBP/EP300 degrader targeting the histone acetyltransferase (HAT) domain, with DC50 value of 1.3 μM in LP1 cells. |
| PC-21652 |
DAS-5-oCRBN
c-Src PROTAC
|
DAS-5-oCRBN is a potent and selective PROTAC for c-Src kinase with DC50 value of 3 nM, without effect on Bcr-Abl. |
| PC-21641 |
DBt-10
DCAF1-BTK-PROTAC
|
DBt-10 is a potent BTK-specific DCAF1 PROTAC with TR-FRET IC50 of 136 nM, potently degrades BTK with DC50 of 137 nM in TMD8 BTK-GFP/mCherry cell-based assays. |
| PC-21526 |
TMX-2172
CDK2/5 PROTAC
|
TMX-2172 is a potent, selective CDK2 and CDK5 dual PROTAC degrader with IC50 of 6.5 nM and 6.8 nM for CDK2/cyclin A and CDK5/p25, respectively. |
