| Cat. No. |
Product Name |
Information |
| PC-25742 |
WZS0347
MITF PROTAC
|
WZS0347 is a potent, selective first-in-class PROTAC degrader of transcription factor MITF with potency of 78% degradation at 0.1 uM in B16F10 melanoma cells. |
| PC-25737 |
OUN20985
CRBN degrader
|
Homo-PROTAC cereblon degrader 1 (OUN20985) is a potent and efficient cereblon (CRBN) degrader with minimal effects on IKZF1 and IKZF3, induces ubiquitination and proteasomal degradation of CRBN. |
| PC-25736 |
MRT-31619
CRBN degrader
|
MRT-31619 is a potent, and selective, CRBN-dependent molecular glue degrader (MGD) of Cereblon (CRBN) with Ki of 7.72 nM and IC50 of 14.1 nM, drives CRBN homo-dimerization and degradation. |
| PC-25719 |
BCL6 PROTAC A19
BCL6 PROTAC
|
BCL6 PROTAC A19 is a potent, selective BCL6 PROTAC degrader with DC50 of 0.034 nM and Dmax of 99% in OCI-LY1 cells. |
| PC-25704 |
LD5097
RIPK1 PROTAC
|
LD5097 is a potent, selective RIPK1 PROTAC degrader with DC50 of 0.7 nM in Jurkat cells, Dmax=96% (24h). |
| PC-25693 |
STAT6 PROTAC 1
STAT6 PROTAC
|
STAT6 PROTAC 1 is a potent, selective STAT6 PROTAC degrader with DC50 of <1 nM. |
| PC-25610 |
ZJK-807
KRAS G12D PROTAC
|
ZJK-807 is a selective, cereblon (CRBN)-based proteolysis-targeting chimera (PROTAC) degrader of KRASG12D with DC50 of 79.5 nM in AsPC-1 cells (Dmax=92%), with minimal impact on wild-type KRAS or other mutants (G12C/S/V, G13D) KRAS proteins. |
| PC-25575 |
BRD9 degrader ZZ7
BRD9 degrader
|
BRD9 degrader ZZ7 is a specific, reversible covalent molecular glue degrader that selectively degrades BRD9, covalently engages DCAF16 at Cys178. |
| PC-25541 |
CDK9 degrader PO-8
CDK9 PROTAC
|
CDK9 degrader PO-8 is a potent, selective iCDK9-based PROTAC degrader of CDK9 with DC50 of 0.26 uM in RAW 264.7 cells. |
| PC-25535 |
dHTC3
BRD4 BD1 degrader
|
dHTC3 is a small molecule, FBXO3-dependent and BD1-specific BRD4 degrader, FBXO3 mediates BRD4 degradation by dHTC3. |
| PC-25534 |
(S)-dHTC1
ENL degrader
|
(S)-dHTC1 is a potent, selective, and stereochemistry-dependent degrader of Eleven-Nineteen-Leukemia protein (ENL) with binding Kd of 49 nM for ENL. |
| PC-25533 |
dHTC1
ENL degrader
|
dHTC1 (rac-dHTC1) is a potent, selective, and stereochemistry-dependent degrader of Eleven-Nineteen-Leukemia protein (ENL) with binding Kd of 45 nM for ENL, recruits CRL4CRBN to ENL through an extended interface of protein-protein and protein-ligand contacts, but only after pre-forming the ENL:dHTC1 complex. |
