| Cat. No. |
Product Name |
Information |
| PC-22587 |
PLX-3618
BRD4 degrader
|
PLX-3618 is a potent, selective monovalent direct degrader of BRD4 (DC50=12.2 nM, HEK293T cells) that acts via the Recruitment of DCAF11, elicits UPS-mediated selective degradation of BRD4, resulting in potent antitumor activity in vitro and in vivo. |
| PC-22585 |
dWIZ-1
WIZ degrader
|
dWIZ-1 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts. |
| PC-22578 |
XZ9002
HDAC3 degrader
|
XZ9002 is a first-in-class HDAC3-specific PROTAC that potently degrades HDAC3 with DC50 of 42 nM in MDA-MB-468 cells. |
| PC-22577 |
YX862
HDAC8 degrader
|
YX862 is a highly potent and selective hydrazide-based HDAC8-PROTAC degrader with DC50 values of 2.6 nM in MDA-MB-231 and 1.8 nM in MCF-7 cells. |
| PC-22559 |
GNF-2-deg
Flaviviruse E protein PROTAC
|
GNF-2-deg is a PROTAC targeting the dengue virus (DENV) envelope (E) protein with DC50 of 0.83 uM, Dmax of 99%, depletes intracellular E via a CRBN- and proteasome-dependent mechanism. |
| PC-22558 |
2-12-2-deg
Flaviviruse E protein PROTAC
|
2-12-2-deg is a PROTAC targeting the dengue virus (DENV) envelope (E) protein with DC50 of 0.21 uM, Dmax of 95%, depletes intracellular E via a CRBN- and proteasome-dependent mechanism. |
| PC-22554 |
ARCC-4
AR degrader
|
ARCC-4 is a potent, selective enzalutamide-based von Hippel-Lindau (VHL)-recruiting androgen receptor (AR) degrader with DC50 of 5 nM in VCaP cells. |
| PC-22553 |
UBX-390
AR degrader
|
UBX-390 is a potent, selective cereblon (CRBN)-based androgen receptor (AR) degrader with DC50 of 2.41 nM in VCaP cells. |
| PC-22538 |
SIAIS039
ROS1 PROTAC
|
SIAIS039 is the first ROS1-specific PROTAC degrader with DC50 of 154.46 nM in HCC78 cells, shows cytotoxic effects in cells carrying ROS1 fusion mutations. |
| PC-22535 |
KI-CDK9d-32
CDK9 degrader
|
KI-CDK9d-32 is a highly potent and selective CDK9 degrader with DC50 of 0.89 nM in MOLT-4 cells (4h) and Dmax of 97.7%, induces rapid reduction of MYC protein levels. |
| PC-22505 |
ZXH-8-004
DENV E protein degrader
|
ZXH-8-004 is a selective and potent PROTAC degrader of the envelope (E) protein of dengue virus (DENV), demonstrates potent antiviral activity.
ZXH-8-004 is cell permeable and able to engage the CRL4CRBN E3 ligase. |
| PC-22493 |
FAK degrader F2
FAK degrader
|
FAK PROTAC F2 is a potent, selective FAK CRBN-recruiting PROTAC degrader based on the FAK inhibitor Ifebemtinib (IN10018) with DC50 of 27.72 nM and 60.10 nM for total FAK and phosphorylated FAK in MDA-MB-231 cells. |
