| Cat. No. |
Product Name |
Information |
| PC-27299 |
SK-3-91
multi-kinase PROTAC
|
SK-3-91 is a PROTAC-type multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases), induces protein (YTHDF2, e.g.) degradation through the ubiquitin biotinylation (E-STUB) pathway, degrades YTHDF2 and inhibits cell proliferation and induces morphological changes. |
| PC-27236 |
NUCC-0227579
CD73 PROTAC
|
NUCC-0227579 (C79) is a potent, first-in-class CD73 PROTAC degrader with DC50 of 0.32 uM, degrades CD73 via the VHL E3 ligase-dependent proteasomal and lysosomal pathways. |
| PC-27235 |
XZ8078
PARP1/IKZF3 degrader
|
XZ8078 is a potent dual-target degrader targeting PARP1 and IKZF3, shows selectivity over PARP1 and IKZF1, has antiproliferative activities against HR-deficient cancer cells with IC50 of 0.006 nM-39.41 nM. |
| PC-27227 |
APH02174
IRAK4 PROTAC
|
APH02174 is a highly potent, selective, orally bioavailable IRAK4 PROTAC degrader with DC50 of 4.01 nM, Dmax=94%. |
| PC-27226 |
APH003
IRAK4 PROTAC
|
APH003 is a highly potent, selective, orally bioavailable IRAK4 PROTAC degrader with DC50 of 1.28 nM, DC90=6.39 nM. |
| PC-27220 |
DW-229
KDM PROTAC
|
DW-229 is a PROTAC degrader targeting Fe(II)/α‑ketoglutarate‑dependent histone lysine demethylases (KDMs), degrades KDM2A, KDM3A, KDM5B, KDM4A‑C, KDM5C, KDM6B in breast cancer cells, shows IC50 < 0.5 μM against MCF‑7 cells and IC50 of 8.87 μM against MDA‑MB‑231 cells, with high cancer cell selectivity. |
| PC-27167 |
NSD2 degrader T9
NSD2 degrader
|
NSD2 degrader T9 is a potent, selective, FBXO22-recruiting NSD2 degrader with DC50 of 0.37 uM in in HEK293T-NSD2-HiBiT cells (4 h). |
| PC-27158 |
NSD2-LDD
NSD2 degrader
|
NSD2-LDD is a cereblon-recruiting and PWWP1-mediated ligand directed degrader (LDD) of histone methyltransferase NSD2, selectively and potently eliminates full length and PWWP1 domain containing NSD2 protein isoforms, induces global loss of H3K36me2 and reverses the oncogenic program of t(4;14) multiple myeloma. |
| PC-27121 |
SMD-1087
SMARCA2 PROTAC
|
SMD-1087 is a highly potent, selective SMARCA2 PROTAC degrader with DC50 of 9 nM, with limited activity against SMARCA4. |
| PC-27068 |
JNJ-1013
IRAK1 PROTAC
|
JNJ-1013 is a highly potent, selective interleukin-1 receptor-associated kinase 1 (IRAK1) PROTAC degrader with DC50 of 3 nM in HBL-1 cells, Dmax=96%. |
| PC-26979 |
R4VP
RNF4 degrader
|
R4VP (RNF4-VHL-Protac-like) is a PROTAC-like molecule that induces proteasomal degradation of RNF4, inhibits the proliferation and sphere formation (SFA) of A375R, a human melanoma cell line that is resistant to PLX4032, as well as SCC1 human squamous skin cancer cells. |
| PC-26978 |
CCW 28-3
BRD4 PROTAC
|
CCW 28-3 is a bifunctional BRD4 PROTAC degrader linking RNF4 ligand CCW16 to BET bromodomain family inhibitor JQ1, degrades BRD4 in a proteasome- and RNF4-dependent manner. |
