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首页-抗体药物偶连体和PROTACs-PROTAC-DW-229
DW-229

Chemical Structure : DW-229

CAS No.:

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DW-229 (DW229)

货号: PC-27220Not For Human Use, Lab Use Only.

DW-229 is a PROTAC degrader targeting Fe(II)/α‑ketoglutarate‑dependent histone lysine demethylases (KDMs), degrades KDM2A, KDM3A, KDM5B, KDM4A‑C, KDM5C, KDM6B in breast cancer cells, shows IC50 < 0.5 μM against MCF‑7 cells and IC50 of 8.87 μM against MDA‑MB‑231 cells, with high cancer cell selectivity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DW-229 is a PROTAC degrader targeting Fe(II)/α‑ketoglutarate‑dependent histone lysine demethylases (KDMs), degrades KDM2A, KDM3A, KDM5B, KDM4A‑C, KDM5C, KDM6B in breast cancer cells, shows IC50 < 0.5 μM against MCF‑7 cells and IC50 of 8.87 μM against MDA‑MB‑231 cells, with high cancer cell selectivity.

物理化学性质&存储条件

分子量 679.77
分子式 C38H41N5O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hex-1-yn-1-yl)-N-(6-(3-hydroxy-2-methyl-4-oxopyridin-1(4H)-yl)hexyl)benzamide

参考文献

1. Johnston A, et al. ACS Omega. 2026;11(18):26421-26437.

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