| Cat. No. |
Product Name |
Information |
| PC-22897 |
HPK1 PROTAC C3
HPK1 PROTAC
|
HPK1 PROTAC C3 is a potent, selective and orally active HPK1 PROTAC degrader with DC50 of 21.26 nM, Dmax of 80.50% in Jurkat cells. |
| PC-22832 |
NCOA4 PROTAC V3
NCOA4 PROTAC
|
NCOA4 PROTAC V3 is a highly efficient VHL-based nuclear receptor coactivator 4 (NCOA4) PROTAC degrader (DC50=3 nM, HeLa cells) and potent ferroptosis inhibitor. |
| PC-22748 |
G9a degrader G9D-4
G9a PROTAC
|
G9D-4 is a first-in-class, potent, selective PRTOAC degrader of protein lysine methyltransferase G9a (EHMT2, KMT1C) with DC50 of 0.1 uM in PANC-1 cells, highly selective over GLP (DC50>10 uM). |
| PC-22612 |
BRD9 PROTAC E5
BRD9 PROTAC
|
BRD9 PROTAC E5 is a highly potent, selective BRD9 PROTAC degrader with DC50 of 16 pM, IC50 of 0.27 nM for antiproliferation in MV4-11 cells. |
| PC-22591 |
UNC8153 TFA
NSD2 PROTAC
|
UNC8153 (UNC 8153) TFA is a selective NSD2-targeted degrader with binding Kd of 24 nM for NSD2, potently and selectively reduces the cellular levels of both NSD2 protein (DC50=350 nM) and the H3K36me2 chromatin mark. |
| PC-22586 |
dWIZ-2
WIZ degrader
|
dWIZ-2 is a small molecular glue degrader of the WIZ transcription factor and CRBN-based small-molecule inducer of fetal hemoglobin (HbF) in erythroblasts. |
| PC-22429 |
R1-ICR-5
RIPK1 PROTAC
|
R1-ICR-5 is a selective and potent RIPK1 PROTAC degrader, triggers VHL-mediated degradation of RIPK1, deregulates TNFR1 and TLR3 signaling, enhances innate immune signaling and necroptosis |
| PC-22382 |
ZNL-02-096
Wee1 PROTAC
|
ZNL-02-096 is a potent, selective CRBN-dependent Wee1 kinase PROTAC degrader, induces potent and rapid Wee1 degradation, while sparing PLK1. |
| PC-22381 |
SKLB-0124
PRMT6 degrader
|
SKLB-0124 is a selective, first-in-class degrader for the protein arginine methyltransferase 6 (PRMT6) with EC50 of 15.4 uM for HCC827 cells. |
| PC-22356 |
GT-653
KDM5B degrader
|
GT-653 is a potent, selective and effective KDM5B PROTAC degrader based on CPI-455, induces KDM5B degradation via PROTAC mechanism and ubiquitin proteasome system dependent manner. |
| PC-22345 |
EP300 degrader MC-1
EP300 PROTAC
|
EP300 degrader MC-1 is a specific, bifunctional small molecule EP300 degrader, preferentially degrades EP300 in a proteasome-dependent manner, does not degrade CREBBP. |
| PC-22174 |
MS181
PRC1 degrader
|
MS181 is a first-in-class CRBN-recruiting and EED-binding (Kd=190 nM) polycomb repressive complex 1 (PRC1) degrader, preferentially degrades PRC1 components BMI1 and RING1B over PRC2 components EZH2 and SUZ12. |
