| Cat. No. |
Product Name |
Information |
| PC-26772 |
MRT-5702
G3BP2 molecular glue degrader
|
MRT-5702 is a specific molecular glue degrader of G3BP2 targeting cereblon (CRBN), forms a CRBN-MRT-5702D-G3BP2 ternary complex to activate the ubiquitin-proteasome system for G3BP2 degradation. |
| PC-26727 |
p300 degrader 27
p300 PROTAC degrader
|
p300 degrader 27 is a potent, paralog-selective p300 protein degrader with DC50 of 22.5 nM in U2OS cells, does not affect CBP. |
| PC-26648 |
LD5095
RIPK1 PROTAC
|
LD5095 is a potent, selective cereblon (CRBN)-recruiting RIPK1 degrader with DC50 of 1.4, 1.2, and 2.3 nM and Dmax>90% for endogenous RIPK1 in WT Jurkat, MOLM14, and U937 cell lines. |
| PC-26640 |
MS108
ENL PROTAC
|
MS108 is a potent, selective eleven-nineteen leukemia protein (ENL) PROTAC degrader with DC50 of 0.6 nM and Dmax > 97% in MV4;11 cells. |
| PC-26588 |
TNG961
HBS1L degrader
|
TNG961 (TNG-961) is a potent, selective and oral CRBN-dependent HBS1L (GSPT3) molecular glue degrader with DC50 of 7 nM and Dmax of 98%, does not affect closely related GSPT1 protein, disrupts the HBS1L/PELO complex. |
| PC-26498 |
Cyclin D1 degrader MS28
Cyclin D1 degrader
|
Cyclin D1 degrader MS28 (XY028-133) is a potent, selective and first-in-class PROTAC degrader of cyclin D1 through recruiting the CDK4/6-cyclin D1 complex to VHL E3 ligase, effectively degrades cyclin D1 in Calu-1 cells with DC50 of 950 nM and Dmax of 90% (8 h). |
| PC-26447 |
SD-965
STAT3 PROTAC
|
SD-965 is a potent, selective, and efficacious STAT3 PROTAC degrader with DC50 of 0.14 uM and Dmax = 85%, inhibits cell growth of MOLM-16 leukemia cell line with IC50 of 1.3 nM. |
| PC-26369 |
HD-TAC7
HDAC3 PROTAC
|
HD-TAC7 is a potent, selective Cereblon-dependent HDAC3 PROTAC degrader with DC50 of 0.32 uM in RAW 264.7 cells. |
| PC-26347 |
Orevandrodeg
Ligand-directed degrader
|
Orevandrodeg (BMS-986460, CC-2043137) is a ligand-directed degrader composed of an E3 ubiquitin ligase-binding moiety that is conjugated, via a linker, to a moiety that targets a prostate specific tumor-associated antigen (TAA), with potential antineoplastic activity, androgen receptor degradation inducer. |
| PC-26133 |
GDCNF-11
GPX4 degrader
|
GDCNF-11 is a potent HSP90 interactome-mediated proteolysis targeting chimera (HIM-PROTAC) GPX4 degarder, potently induces ferroptosis via HSP90-mediated ubiquitin-proteasomal degradation of GPX4 in HT-1080 cells with DC50 of 0.08 uM. |
| PC-26132 |
dGPX4
GPX4 PROTAC
|
dGPX4 is a potent GPX4 PROTAC degrader, depletes GPX4 via proteasomal protein degradation, induces cell-selective ferroptosis by targeting cancer cell microenvironment. |
| PC-26131 |
GDAz-3
GPX4 degrader
|
GDAz-3 is a potent GPX4-targeting HSP70-PROTAC, potently and rapidly eliminates GPX4 in HT1080 cells (DC50=0.13 uM), thereby triggering ferroptosis with high selectivity. |
