| Cat. No. |
Product Name |
Information |
| PC-28771 |
AML874
CDK8/CDK19 inhibitor
|
AML874 is a potent selective CDK8/CDK19 inhibitor with IC50 of 62 nM (CDK8), targets the Mediator complex and disrupts Mediator-dependent transcription, shows selective anti-leukemic activity. |
| PC-28745 |
ZLC853
CDK12/13 inhibitor
|
ZLC853 is a potent, selective, and orally bioavailable covalent inhibitor of CDK12/13 with IC50 of 40.0 nM and 18.2 nM respectively, inhibits VCaP cell proliferation with IC50 of 13.7 nM. |
| PC-28695 |
ON013100
Mitotic inhibitor
|
ON013100 (ON-013100) is a small molecule mitotic inhibitor, potently inhibits the expression of CDK4, p53, mouse double minute 2 (MDM2), and Cyclin D, as well as increases cyclin B expression, alteres the growth and cell cycle status of MCL lines. |
| PC-28564 |
INCB127443
CDK2 inhibitor
|
INCB127443 is a potent, selective and orally bioavailable CDK2 inhibitor with IC50 of 0.99 nM (CDK2/cyclin E1), 316-fold selective over CDK1. |
| PC-28533 |
OKI-1546
CDK12/13 inhibitor
|
OKI-1546 is a potent, selective, covalent and orally bioavailable CDK12/13 inhibitor with IC50 of 15 nM (CDK12), shows 649-, 81-, 11-, and 64-fold selective over CDKs 1, 2, 7, and 9, respectively. |
| PC-28201 |
JH-XVI-178
CDK8/19 inhibitor
|
JH-XVI-178 is a highly potent and selective inhibitor of CDK8/19 with IC50 of 1/2 nM respectively. |
| PC-27703 |
UOM-005636
Cyclin K degrader
|
UOM-005636 is a molecular glue degrader (MGD) that mediates the CRL4-dependent proteolysis of cyclin K with IC50 of 85 nM in OCI-AML5 cells, mediates cyclin K degradation through DDB1 bridging the CRL4 complex. |
| PC-27702 |
Cyclin K MGD S656
Cyclin K degrader
|
Cyclin K MGD S656 is a molecular glue degrader (MGD) that mediates the CRL4-dependent proteolysis of cyclin K with IC50 of 743 nM in OCI-AML5 cells, mediates cyclin K degradation through the cullin RING ubiquitin ligase complex. |
| PC-27634 |
ZJC-11
CDK7 inhibitor
|
ZJC-11 is a potent, selective and covalent cyclin-dependent kinase 7 (CDK7) inhibitor with IC50 of 5.4 nM, has >100-fold selectivity over CDK1/2/9. |
| PC-27510 |
Tudociclib
CDK2 inhibitor
|
Tudociclib (INCB123667) is a potent and selective, orally available small molecule inhibitor of CDK2 with IC50 of <20 nM, is inactive against CDK1, CDK4, CDK6, CDK7, and CDK9. |
| PC-27409 |
CT7439
CDK12/13 inhibitor, Cyclin K degrader
|
CT7439 (CT-7439) is a potent, selective and oral cyclin-dependent kinases CDK12/CDK13 inhibitor and monovalent glue degrader of cyclin K (CCNK), inhibites OV-90 cell growth with IC50 of 4.4 nM. |
| PC-27231 |
XL413
CDC7 inhibitor
|
XL413 (BMS-863233) is a potent, selective, ATP competitive serine/threonine kinase CDC7 inhibitor with IC50 of 3.4 nM. |
