| Cat. No. |
Product Name |
Information |
| PC-61246 |
Roniciclib
CDK inhibitor
|
Roniciclib (BAY 1000394) is a potent, orally active, pan-CDK inhibitor with IC50 of 7/9/11 nM for CDK1/2/4 respectively, inhibits transcriptional CDK9/7 with IC50 of 5-25 nM. |
| PC-61180 |
CDK7 and 9 inhibitor 14
CDK7/9 inhibitor
|
CDK7/9-IN-14 is a potent, selective transcriptional CDK inhibitor with Ki of 2.3 and 0.38 nM for CDK7 and CDK9, respectively. |
| PC-61146 |
CCT-251921
CDK8/CDK19 inhibitor
|
CCT-251921 (CCT251921) is a potent, selective, and orally bioavailable inhibitor of CDK8 and CDK19 with IC50of 2.3 nM and 2.6 nM respectively. |
| PC-61143 |
AZD 5597
CDK1/2 inhibitor
|
AZD 5597 is a highly potent cyclin-dependent kinase (CDK) inhibitor with IC50 of 2 nM for both CDK1 and CDK2. |
| PC-61136 |
CDK2 inhibitor 73
CDK2 inhibitor
|
CDK2 inhibitor 73 (CDK2-IN-4) is a potent, selective CDK2 inhibitor with IC50 of 44 nM for CDK2/cyclin A, displays 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM). |
| PC-61031 |
Voruciclib
CDK9 inhibitor
|
Voruciclib (P1446A-05) is a potent, selective and orally bioavailable CDK9 inhibitor with Ki of 0.63 nM and 1.68 nM for CDK9/cyclinT2 and CDK9/cyclinT1, respectively. |
| PC-61020 |
Cdc7 inhibitor 7c
Cdc7 inhibitor
|
Cdc7 inhibitor 7c (Cdc7-IN-7c) is a highly potent, selective and time-dependent Cdc7 kinase inhibitor with IC50 of 0.7 nM with slow dissociation property, with 200-fold and >14,000-fold selectivity over CDK2 and ROCK1, respectively. |
| PC-60961 |
YKL-1-116
CDK7 inhibitor
|
YKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs. |
| PC-60894 |
Cortistatin A
CDK8/19 inhibitor
|
Cortistatin A is a potent and selective inhibitor of mediator-associated kinase CDK8 (IC50=12 nM) and its paralogue CDK19. |
| PC-60893 |
BRD6989
CDK8 inhibitor
|
BRD6989 is a potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex. |
| PC-60582 |
(R)-DRF053 dihydrochloride
CK1/CDK inhibitor
|
(R)-DRF053 dihydrochloride (DRF053) is a potent, cell-permeable, dual CK1/CDK inhibitor with IC50 of 14 nM, 220 nM and 80 nM for CK1, CDK5/p25 and CDK1/cyclin B, respectively. |
| PC-60539 |
BAY-958
CDK9 inhibitor
|
BAY-958 (BAY958, LDC526) is a potent, selective PTEFb/CDK9 inhibitor with IC50 of 5 nM against CDK9/CyclinT1. |
