| Cat. No. |
Product Name |
Information |
| PC-23060 |
Tacaciclib
CDK7 inhibitor
|
Tacaciclib (XL102, AUR102) is a potent, orally bioavailable, highly selective covalent CDK7 inhibitor. |
| PC-23058 |
BPI-16350
CDK4/6 inhibitor
|
BPI-16350 (Tibremciclib) is a highly potent, selective CDK4/6 inhibitor with IC50 of 2.21 nM and 0.4 nM for CDK4/cyclinD1 and CDK6/cyclinD1, with less inhibition of CDK9 (IC50=91.6 nM). |
| PC-23046 |
Myrtleciclib
CDK4/6/9 inhibitor
|
Myrtleciclib (VS2 370) is a potent, selective CDK4/6/9 inhibitor. |
| PC-23020 |
YK-2168 hydrochloride
CDK9 inhibitor
|
YK-2168 hydrochloride is a potent, selective CDK9 inhibitor with IC50 of 5.9 nM, 45- and 72-fold selective over CDK1 and CDK2. |
| PC-23019 |
YK-2168
CDK9 inhibitor
|
YK-2168 is a potent, selective CDK9 inhibitor with IC50 of 5.9 nM, 45- and 72-fold selective over CDK1 and CDK2. |
| PC-22927 |
TMX-2039
CDK inhibitor
|
TMX-2039 is a potent, multi-CDK inhibitor with low nanomolar enzymatic IC50s for both cell cycle CDKs (CDK1, CDK2, CDK4, and CDK6) and transcriptional CDKs (CDK7 and CDK9). |
| PC-22926 |
TMX-3013
CDK inhibitor
|
TMX-3013 is a potent, multi-CDK inhibitor with IC50 of 0.9/<0.5/0.5/24.5/15.6 nM for CDK1/2/5/4/6 respectively. |
| PC-22841 |
CDKL3 inhibitor HZ1
CDKL3 inhibitor
|
CDKL3 inhibitor HZ1 (C3I-22) is a first-in-class, specific inhibitor of CDKL3 (Cyclin-dependent kinase like 3) inhibitor with Kd of 5.16 uM, blocks CDKL3 mediated cell cycle progression both in vitro and in vivo |
| PC-22396 |
CDKL2 inhibitor 9
CDKL2 inhibitor
|
CDKL2 inhibitor 9 is a selective cyclin-dependent kinase-like 2 (CDKL2, KKIAMRE, P56) chemical probe inhibitor with enzyme IC50 of 230 nM in radiometric enzymatic assays. |
| PC-22118 |
AZD8421
CDK2 inhibitor
|
AZD8421 (AZD-8421) is a potent, highly selective CDK2 inhibitor with IC50 of 9 nM, >300-fold selectivity over CDK9. |
| PC-22032 |
KY-273
CDK8/19 inhibitor
|
KY-273 (KY273) is a potent, specific CDK8/19 inhibitor with IC50 of 29.1 and 44.7 nM respectively, promotes osteoblast differentiation and has cortical-bone-selective osteogenic effects. |
| PC-21964 |
dCeMM4
Cyclin K degrader
|
dCeMM4 is a small glue degrader, induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex. |
