R547 | CDK inhibitor | Probechem Biochemicals

Chemical Structure : R547

CAS No.: 741713-40-6

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R547 (CDK inhibitor R547)

货号: PC-42067Not For Human Use, Lab Use Only.

R547 is a potent, selective and ATP-competitive CDK inhibitor with Ki of 1/3/1 nM for CDK1/2/4, respectively.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥2980	In stock
50 mg	￥4580	In stock
100 mg		Get quote

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生物&药学活性

R547 is a potent, selective and ATP-competitive CDK inhibitor with Ki of 1/3/1 nM for CDK1/2/4, respectively.
R547 has no activity against a large panel of serine/threonine and tyrosine kinases.
R547 inhibits the growth of various human tumor cell lines (HCT116 cell line IC50=80 nM), blocks G1 and G2 phases, induces apoptosis and reduces phosphorylation of Rb.
R547 demonstrates significant in vivo efficacy in the HCT116 human colorectal tumor xenograft model in nude mice.

物理化学性质&存储条件

分子量	441.4522
分子式	C18H21F2N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methanone, [4-amino-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-5-pyrimidinyl](2,3-difluoro-6-methoxyphenyl)-

参考文献

1. Chu XJ, et al. J Med Chem. 2006 Nov 2;49(22):6549-60.

2. DePinto W, et al. Mol Cancer Ther. 2006 Nov;5(11):2644-58.

R547 (CDK inhibitor R547)

生物&药学活性

物理化学性质&存储条件

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R547 (CDK inhibitor R547)

生物&药学活性

物理化学性质&存储条件

参考文献

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