| Cat. No. |
Product Name |
Information |
| PC-20622 |
ICG-001
TCF/beta-catenin inhibitor
|
ICG-001 (ICG001) is a specific small molecule inhibitor of TCF/beta-catenin, antagonizes β-catenin/TCF-mediated transcription with IC50 of 3 uM. |
| PC-20175 |
IMU1003
Wnt/β-catenin inhibitor
|
IMU1003 (IMU-1003) is a small molecule inhibitor of Wnt/β-catenin signaling, decreases β-catenin levels and inhibits target gene expression that promotes cancer cell proliferation. |
| PC-38652 |
PTK7/β-catenin inhibitor 01065
PTK7/β-catenin inhibitor
|
PTK7/β-catenin inhibitor 01065 is a small molecule inhibitor of PTK7/β-catenin interaction (IC50=8.9 uM) targeting the Wnt pathway signaling, induces antiproliferative and antitumor effects in vitro in CRC cells harboring β-catenin or adenomatous polyposis coli (APC) mutations. |
| PC-38567 |
E722-2648
β-catenin/BCL9 inhibitor
|
E722-2648 (Compound C-1) is a novel specific and competitive small molecule β-catenin/BCL9 interaction inhibitor with ITC KD of 1.05 uM and IC50 of 9 uM, blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer. |
| PC-38409 |
Miclxin
MIC60 inhibitor
|
Miclxin (DS37262926) is a small molecule inhibitor of MICOS component MIC60, induces mitochondrial stress response in a mutant β-catenin-dependent manner in β-catenin-mutated HCT116 cells, directly binds to mitochondrial inner membrane complex protein MIC60 (SPR Kd=11.9 uM). |
| PC-73231 |
GB1874
Beta-catenin-TCF4 inhibitor
|
GB1874 is an inhibitor of the Wnt pathway that targets the β-catenin-TCF4 interaction. |
| PC-73060 |
RX-5902
P-p68 inhibitor
|
RX-5902 (Supinoxin, RX5902) is a small molecule inhibitor of phosphorylated-p68 RNA helicase (P-p68) and attenuates nuclear shuttling of β-catenin. |
| PC-72708 |
ZW4864
BCL9/β-catenin inhibitor
|
ZW4864 (ZW-4864) is an orally bioavailable small-molecule that binds with β-catenin and selectively disrupts the PPI between BCL9 and β-catenin, while sparing the β-catenin/E-cadherin PPI. |
| PC-72072 |
β-catenin inhibitor C2
β-catenin inhibitor
|
β-catenin inhibitor C2 is a novel potent selective β-catenin inhibitor with Kd of 54.96 nM, directly to ARM domain of β-catenin. |
| PC-35350 |
SKL2001
Axin/β-catenin inhibitor
|
SKL2001 is a specific small molecule activator (agonist) of the Wnt/β-catenin pathway, stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction. |
| PC-35329 |
E-7386
CBP/beta-catenin inhibitor
|
E-7386 (E7386) is a potent, orally active modulator of CBP/beta-catenin, disrupts the interaction and inhibits canonical Wnt signaling pathway /TCF reporter gene activity in LiCl-stimulated HEK-293 and MDA-MB-231 with IC50 of 55 and 73 nM, respectively. |
| PC-62707 |
β-catenin-IN-11a
β-catenin inhibitor
|
β-catenin-IN-11a is a β-catenin/CD44/Nanog axis inhibitor, docks into the β-catenin allosteric site and interferes β-catenin/TCF-4 complex. |
