ZW4864 | BCL9/β-catenin inhibitor | Probechem Biochemicals

Chemical Structure : ZW4864

CAS No.: 2632259-92-6

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ZW4864 (ZW-4864)

货号: PC-72708Not For Human Use, Lab Use Only.

ZW4864 (ZW-4864) is an orally bioavailable small-molecule that binds with β-catenin and selectively disrupts the PPI between BCL9 and β-catenin, while sparing the β-catenin/E-cadherin PPI.

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5 mg	￥4280	In stock
10 mg	￥7280	In stock
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生物&药学活性

ZW4864 (ZW-4864) is an orally bioavailable small-molecule that binds with β-catenin and selectively disrupts the PPI between BCL9 and β-catenin, while sparing the β-catenin/E-cadherin PPI.
ZW4864 dose-dependently suppresses β-catenin signaling activation, downregulates oncogenic β-catenin target genes, and abrogates invasiveness of β-catenin-dependent cancer cells.
ZW4864 effectively suppresses β-catenin target gene expression in the patient-derived xenograft mouse model.
ZW4864 is a selective chemical probe to explore β-catenin-related biology and a drug-like small-molecule β-catenin/BCL9 disruptor.

物理化学性质&存储条件

分子量	570.738
分子式	C33H42N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(4-(1H-pyrazol-4-yl)benzyl)-N-cyclopropyl-1-(3-((2-methyl-1-oxo-1-(piperazin-1-yl)propan-2-yl)oxy)phenyl)piperidine-3-carboxamide

参考文献

1. Zhen Wang, et al. J Med Chem. 2021 Aug 26;64(16):12109-12131.

ZW4864 (ZW-4864)

生物&药学活性

物理化学性质&存储条件

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ZW4864 (ZW-4864)

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